# Pediatric HIV/AIDS Cohort Study (PHACS) 2020

> **NIH NIH P01** · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2020 · $17,150,481

## Abstract

Project Summary/Abstract
Each year, there are more than 1 million pregnant women living with HIV (PWLHIV) who receive antiretroviral
medications (ARVs) for treatment and perinatal and postnatal HIV transmission prevention, with new ARVs
introduced at a rapid pace. Although maternal use of ARVs has successfully reduced perinatal HIV
transmission, there remains a clear need to monitor the safety of in utero ARV for infant and child health.
Currently, 1.7 million children under the age of 15 are living with HIV globally – the vast majority with perinatally
acquired HIV infection (PHIV) - who are aging into young adulthood. In the US, the Centers for Disease Control
and Prevention (CDC) estimates that in 2016, there were 11,915 persons with PHIV in the U.S, including 1,814
children younger than 13 years of age and 10,101 adolescents and young adults. The lifelong impact of HIV
and ARVs on their overall health is unknown as they transition into adulthood and adult HIV care.
The Pediatric HIV/AIDS Cohort Study (PHACS) is a network, initiated in 2007, currently consisting of two
prospective cohort studies: The Surveillance Monitoring for ART Toxicities Study (SMARTT), with over
4,000 infants, children and youth with perinatal HIV exposure but who are uninfected (PHEU), and the series of
Adolescent Master Protocols (AMP, AMP Up and AMP Up Lite) studies following 1,000 young adults with
perinatal HIV, and a comparison cohort of young adults with PHEU. These studies are designed to answer
questions regarding the short and long term outcomes of HIV infection and ARV exposure or treatment.
PHACS 2020 is designed as a Program Project P01 grant, consisting of the following four support Cores:
Scientific Administrative Core (SAC), Data Resources Core (DRC), Health Education and Community Core
(HECC), and the Epidemiological and Statistical Methods Core (ESC) to provide scientific, site and cohort
infrastructure, data management and analysis, health education and community input, as well as
epidemiological and statistical support to four Research Projects: 1) SMARTT; 2) The Adolescent Master
Protocol (AMP) Up Series (the AMP Up Series); 3) Natural History of Cervical Intraepithelial Neoplasia
(CIN) and Human Papillomavirus (HPV) in HPV Vaccinated Youth with PHIV (HPV); and the TERBO
BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions
And Intrinsic Networks (TERBO BRAIN). This multidisciplinary, interdisciplinary, transdisciplinary and
synergistic P01 will address the most critical scientific questions for children, youth and young adults exposed
to or living with HIV.

## Key facts

- **NIH application ID:** 10065440
- **Project number:** 1P01HD103133-01
- **Recipient organization:** HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** Ellen Gould Chadwick
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $17,150,481
- **Award type:** 1
- **Project period:** 2020-09-18 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10065440

## Citation

> US National Institutes of Health, RePORTER application 10065440, Pediatric HIV/AIDS Cohort Study (PHACS) 2020 (1P01HD103133-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10065440. Licensed CC0.

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