# SOMMA-BRAIN

> **NIH NIH R01** · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · 2020 · $325,698

## Abstract

We propose to acquire new neuroimaging measures concurrent with muscle measures in 40
adults participating in the Pittsburgh Clinical Center R01AG059416, “Study of Muscle and
Mobility in Aging (SOMMA). The goal of SOMMA is to study muscle aging as it relates to
disability. The goal of the proposed expanded SOMMA-BRAIN is to identify, for the first time,
novel modifiable shared brain-muscle energy characteristics best predicting resilience to fatigue
and loss of mobility. By promoting an integrated study of central and peripheral causes of
fatigue, this project will provide novel targets for prevention and treatment of fatigue.
Additionally, this project would discover modifiable processes in muscle that may influence
processes in the brain to, in turn, influence cognitive performance. The data would support a
new grant application to NIA to expand the aims of SOMMA, as well as the number of
participants and widen the eligibility criteria.

## Key facts

- **NIH application ID:** 10065711
- **Project number:** 3R01AG059416-03S1
- **Recipient organization:** CALIFORNIA PACIFIC MED CTR RES INSTITUTE
- **Principal Investigator:** STEVEN RON CUMMINGS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $325,698
- **Award type:** 3
- **Project period:** 2018-06-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10065711

## Citation

> US National Institutes of Health, RePORTER application 10065711, SOMMA-BRAIN (3R01AG059416-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10065711. Licensed CC0.

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