# Form-Function Relationships in Femoroacetabular Impingement Syndrome

> **NIH NIH F32** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $67,225

## Abstract

PROJECT SUMMARY/ABSTRACT
By some estimates, femoroacetabular impingement syndrome (FAIS) accounts for 82% of hip osteoarthritis
cases. Patients present with loss of femoral head sphericity, reduction in femoral-neck offset, and/or an
excessively prominent acetabular wall, and report position- or motion-related pain. The theory of FAIS
pathophysiology is that pathoanatomy causes pathomechanics. However, quantitative understanding of this
disease is lacking. Few investigators have analyzed the relationship between hip anatomy and biomechanics
in FAIS patients; those that have relied on 2D measures that incompletely describe hip shape. Based on these
2D shape metrics, ~35% of the general population carries a ‘silent’ form of the disease, which has hindered
progress to understand why FAI morphology causes damage. To advance understanding of FAIS
pathophysiology, a cross-sectional study of FAIS patients and controls will be performed. Aim 1 will quantify
pathomorphology of FAIS. Hip anatomy will be visualized and compared using statistical shape modeling
(SSM). Notably, SSM compares shape over the 3D continuum, rather than relative to a single, 2D image. The
central hypothesize is that SSM will detect differences in 3D shape of symptomatic and asymptomatic hips;
further, this difference will occur whether controls are analyzed together or as anatomic subgroups identified
via cluster analysis. Aim 1 will improve clinical understanding of this disease and inform development of better
techniques to evaluate hip anatomy. Aim 2 will quantify pathokinematics of FAIS. Hip motion will be measured
during functional activities in FAIS patients and controls. The central hypothesis is that hip kinematics will differ
between FAIS patients and controls and that significant relationships exist between hip shape and hip
kinematics; further, controls with hip shape similar to FAIS patients will have altered kinematics compared to
controls that do not. Aim 2 will guide development of treatment options through a better understanding of
compensatory mechanisms that occur across groups. The training plan is tailored to facilitate achievement of
the applicant’s career goals through development of scientific and professional skills and opportunities to
generate and disseminate research findings. The training plan enables collaboration between the applicant and
sponsors in the University of Utah Departments of Orthopaedics and Physical Therapy, and Scientific
Computing and Imaging Institute. The sponsor team (Drs. Andrew Anderson (primary mentor), Shireen
Elhabian, Kenneth “Bo” Foreman, Stephen Aoki) is well-qualified to train the applicant in computational
biomechanics, analysis techniques for high-dimensional data, motion analysis, and clinical treatment of hip
pathology. The sponsor team has a strong history of successful collaboration, mentorship, publication, and
funding. Receipt of an F32 fellowship will enhance synergy between the applicant and sponsors, enable the
ap...

## Key facts

- **NIH application ID:** 10066165
- **Project number:** 1F32AR078019-01
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Joseph Mozingo
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $67,225
- **Award type:** 1
- **Project period:** 2020-08-17 → 2023-08-16

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10066165

## Citation

> US National Institutes of Health, RePORTER application 10066165, Form-Function Relationships in Femoroacetabular Impingement Syndrome (1F32AR078019-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10066165. Licensed CC0.

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