# Notch in the Vasculature

> **NIH NIH F32** · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2020 · $67,446

## Abstract

Project Description and Summary
 The objective of this proposal is to evaluate and characterize the interplay between the
lipid-derived, vasoactive factor Sphingosine-1-phosphate (S1P) and Notch1 Receptor in the
vasculature. S1P and Notch1 are both critical, potent regulators of cell-cell adhesion, barrier, and
angiogenesis. Currently, it is thought that these proteins act through distinct, separate pathways.
However, the investigator has recently found that these two pathways are highly interconnected,
such that S1P activates Notch1 to promote Rac1 activation and barrier enhancement. The goals
of this proposal are to characterize why, how, and in what contexts Notch1 is essential in S1P
signaling. These goals will be addressed through three Aims. Specific Aim 1 will evaluate and
characterize the role of cortical Notch in S1P-mediated barrier. Specific Aim 2 will investigate how
S1P activates Notch1. Specific Aim 3 will explore the interplay between S1P Receptor1 and
cortical Notch1 in angiogenic sprouting and morphogenesis. Together, these studies will unveil
and characterize a novel connection between two key proteins in barrier and angiogenic
regulation. Furthermore, connecting Notch to S1P will open up a new suite of drugs and therapies
to target and control Notch signaling, as G-coupled protein receptors are common druggable
targets.

## Key facts

- **NIH application ID:** 10067904
- **Project number:** 1F32HL154664-01
- **Recipient organization:** BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- **Principal Investigator:** Jennifer Bays
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $67,446
- **Award type:** 1
- **Project period:** 2020-08-07 → 2021-08-06

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10067904

## Citation

> US National Institutes of Health, RePORTER application 10067904, Notch in the Vasculature (1F32HL154664-01). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10067904. Licensed CC0.

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