# Disruption of epigenetic regulation of enhancers in the germinal center reaction drives clonal evolution in Follicular Lymphoma

> **NIH NIH F31** · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $45,520

## Abstract

PROJECT SUMMARY/ABSTRACT
Follicular Lymphoma (FL) is the second most common form of non-Hodgkin's lymphoma, accounting for 20-
30% of non-Hodgkin's lymphoma diagnoses. Though FL is an indolent disease, it eventually transforms into
more aggressive, incurable forms of lymphoma. FL is hallmarked by the anti-apoptotic IGH/BCL2 translocation,
which is often accompanied by a mutation in an epigenetic gene. Here, we propose to investigate the roles of
these mutations in epigenetic genes, specifically KMT2D and CREBBP due to their high rate of occurrence, in
the development and transformation process of FL. In our first aim, we plan to use mixed bone marrow chimera
mouse models to determine the role of these mutations in driving early clonal evolution of the disease. In our
second aim, we plan to then characterize the gene expression and chromatin accessibility of the resulting
lymphoma to determine how these mutations cooperate to drive progression through epigenetic reprogramming
of the tumor.

## Key facts

- **NIH application ID:** 10068875
- **Project number:** 1F31CA254302-01
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Christopher Russell Chin
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $45,520
- **Award type:** 1
- **Project period:** 2020-07-06 → 2023-07-05

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10068875

## Citation

> US National Institutes of Health, RePORTER application 10068875, Disruption of epigenetic regulation of enhancers in the germinal center reaction drives clonal evolution in Follicular Lymphoma (1F31CA254302-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10068875. Licensed CC0.

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