# Role of Sulfiredoxin in Colorectal Cancer Development

> **NIH NIH R01** · UNIVERSITY OF KENTUCKY · 2021 · $349,912

## Abstract

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer death
in both men and women in USA and worldwide. One of the major causes of colorectal cancer mortality is due
to the spreading of cancer cells from primary tumor sites to distant organs, a process known as cancer cell
invasion and metastasis. This process is coordinately regulated by various biological molecules and their
associated signaling pathways. The long-term objective of my research is to understand colon tumorigenesis
and metastatic process by identifying critical molecular drivers, and to understand their function mechanisms to
develope effective ways for targeted cancer therapy. Sulfiredoxin is a novel redox enzyme that has a critical
role of promoting tumorigenesis and metastasis of colorectal cancer. In this project, our goals are to
understand molecular mechanisms by which Sulfiredoxin promotes cancer cell invasion and metastasis, and to
test the efficacy of a novel small molecule inhibitor of Srx in blocking human colorectal cancer invasion and
metastasis using cell culture as well as mouse models.

## Key facts

- **NIH application ID:** 10069307
- **Project number:** 5R01CA222596-04
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** Qiou Wei
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $349,912
- **Award type:** 5
- **Project period:** 2018-01-01 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10069307

## Citation

> US National Institutes of Health, RePORTER application 10069307, Role of Sulfiredoxin in Colorectal Cancer Development (5R01CA222596-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10069307. Licensed CC0.

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