# TAXI-CAB: Transfusion and Anemia eXpert Initiative - Control/Avoidance of Bleeding

> **NIH NIH R13** · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $10,000

## Abstract

PROJECT SUMMARY
Plasma and platelet transfusions are frequently prescribed to critically ill children who are actively bleeding or
at risk of bleeding. These fragile children may require plasma and/or platelet transfusions given their underlying
organ dysfunction, including suppression of bone marrow and/or hepatic insufficiency, medications that may
suppress their functional ability to clot, consumption, and frequent invasive procedures. Despite their possible
therapeutic benefits, both plasma and platelet transfusions have been independently associated with
significant morbidity and mortality in this population. Given the significant dangers, guidelines must be
available to help intensivists weigh the risks and benefits to their patients. Current recommendations do not
adequately or reliably address clinical scenarios specific to critically ill children. The Transfusion and Anemia
eXpert Initiative – Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care
Blood Research Network (BloodNet), the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), the
Society for the Advancement of Blood Management (SABM), the Network for the Advancement of blood
management, Haemostasis and Thrombosis (NATA), the International Society of Blood Transfusions (ISBT)
and the Society for Critical Care Medicine (SCCM), proposes a conference series led by international and
multidisciplinary experts to develop pediatric critical care blood management consensus for clinical guidance
and future research efforts. This group will create a comprehensive series of consensus statements via an
organized and structured process over 18 months to outline existing data and future research foci in the area
of plasma and platelet transfusions in critically ill children. TAXI-CAB has obtained agreements of participation
from a diverse group of 25 experts in the field from five countries representing eight pediatric sub-specialties.
The consensus statements will include specific strategies for adaptive dissemination and implementation into
various clinical and research environments. In addition, the TAXI-CAB process, modeled after the highly
successful TAXI program which developed guidelines for red blood cell transfusion in critically ill children, has
been endorsed by six international organizations who are committed to the broad dissemination of the
consensus recommendations. TAXI-CAB seeks to develop evidence-based guidance for pediatric intensivists
to encourage the use of plasma and platelet transfusions in the right scenarios to maximize their clinical benefit
and minimize their harm.

## Key facts

- **NIH application ID:** 10070431
- **Project number:** 1R13HL154544-01
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Marianne Nellis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $10,000
- **Award type:** 1
- **Project period:** 2020-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10070431

## Citation

> US National Institutes of Health, RePORTER application 10070431, TAXI-CAB: Transfusion and Anemia eXpert Initiative - Control/Avoidance of Bleeding (1R13HL154544-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10070431. Licensed CC0.

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