# Harnessing the Microbiome for Disease Prevention and Therapy

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2020 · $12,500

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled Harnessing the Microbiome for Disease
Prevention and Therapy organized by Drs. Eric G. Pamer, Laurie E. Comstock and Alan Walker. The
conference will be held in Keystone, Colorado from January 17-21, 2021.
Our understanding of the microbiome is advancing rapidly, and continues to productively move through the
discovery phase, with numerous correlations being established between specific commensal microbes or
microbiota compositions and a wide range of diseases that includes infections, inflammatory conditions,
metabolic disease, autoimmunity and neurologic syndromes. The initial discovery of these potentially important
correlations has led many laboratories around the world to probe the molecular mechanisms that form the
causal link between specific commensal microbes and disease development, progression and resolution.
Although there have been great advances, culturing many of the prevalent and metabolically active obligate
anaerobic commensals remains a challenge. Exciting advances, however, are emerging from laboratories
developing tools to genetically manipulate key commensal organisms, facilitating experimental studies that are
identifying the small, bioactive molecules they produce, some of which have therapeutic potential. Studies of
the impact of bacteriophage on the microbiota also suggest that they may have therapeutic potential. This
Keystone conference will focus on recent advances that demonstrate, at the cellular and molecular level, the
impact of the microbiota and its products on disease susceptibility/resistance, with an emphasis on microbial
and host metabolism, inter-microbial interactions and the amelioration of diseases.

## Key facts

- **NIH application ID:** 10070471
- **Project number:** 1R13AI154725-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** Thale Cross Jarvis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $12,500
- **Award type:** 1
- **Project period:** 2020-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10070471

## Citation

> US National Institutes of Health, RePORTER application 10070471, Harnessing the Microbiome for Disease Prevention and Therapy (1R13AI154725-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10070471. Licensed CC0.

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