# Tissue Plasticity: Preservation and Alteration of Cellular Identity

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2020 · $12,000

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled Tissue Plasticity: Preservation and
Alteration of Cellular Identity, organized by Drs. Ophir Klein, Ramesh A. Shivdasani and Stacey S. Huppert.
The conference will be held in Park City, Utah from October 4-7, 2020.
Cellular plasticity, the ability to acquire new identities or adopt alternative fates, occurs in normal physiology
and disease states. Researchers are just beginning to understand how plasticity contributes to homeostasis
and regeneration in the setting of tissue injury. Alterations in cell fate can be harnessed to treat disease, but
uncontrolled plasticity can destabilize cell commitment and contribute toward neoplasia. The cellular and
molecular underpinnings of cellular plasticity provide insights into disease processes and enable new
therapies. This conference will explore the diverse mechanisms that underlie plasticity in different tissues and
contexts. By bringing together leading scientists in stem cell, developmental, regenerative, and cancer biology,
this interdisciplinary conference will highlight common principles and unique features of cellular plasticity in
different tissues and examine the therapeutic potential of this process. The conference represents a unique
opportunity for researchers in diverse fields to visit evolving concepts in cellular plasticity and the molecular
mechanisms and physiological consequences of altered adult cell identity in vivo. While the topic has been
included marginally at other conferences (i.e., conferences on stem cell biology, regeneration, epigenetics, and
cancer) only this Keystone Symposia conference, first held in 2019, has focused on cellular plasticity across
mammalian tissues. This conference will assemble speakers from diverse disciplines and organ systems to
identify cross-cutting themes and provide a forum for investigators to explore common underlying mechanistic
principles and therapeutic potential.

## Key facts

- **NIH application ID:** 10070713
- **Project number:** 1R13DE030021-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** Thale Cross Jarvis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $12,000
- **Award type:** 1
- **Project period:** 2020-09-09 → 2021-09-08

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10070713

## Citation

> US National Institutes of Health, RePORTER application 10070713, Tissue Plasticity: Preservation and Alteration of Cellular Identity (1R13DE030021-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10070713. Licensed CC0.

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