# Skin-Immune Crosstalk

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2020 · $15,900

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled Skin Immune Crosstalk organized by Drs.
Anna Di Nardo, Daniel H. Kaplan and Nathalie Boulanger. The conference will be held in Breckenridge,
Colorado from February 15-18, 2021.
Skin is a barrier environment where immune cells interact with the unique skin environment to maintain tissue
homeostasis and induce immune responses. Skin immune cells can be recruited from the circulation, but many
reside in the skin where they are strategically located at the barrier interface within a complex stromal matrix in
proximity with commensal bacteria and the external environment. Recent discoveries have radically changed
our knowledge of the skin immune system including the interplay between different skin-resident immune cell
types and the realization that skin immune cells interact with non-immune compartments in the skin. Skin-
resident immune cells are shaped by the cutaneous microbiome and interact with the peripheral nervous
system. These complex interactions result in efficient host defense against many pathogens, but some
bacteria, fungi, viruses and vector-borne pathogens have evolved mechanisms to evade these systems. This
conference will bring together immunologists, skin biologists, and dermatologists to introduce all groups to
these new discoveries, challenges, and therapeutic opportunities. We will provide the attendees with a clear
understanding that the host skin is a complex environment designed to tolerate commensals and respond to
pathogens. Joining with a concurrent vector-borne disease meeting will enable microbiologists and vector
biologists to exchange knowledge with immunologists and skin biologists, allowing for consideration of how
new discoveries regarding skin-immune cross talk can inform our understanding of vector-borne pathogen
transmission.

## Key facts

- **NIH application ID:** 10070758
- **Project number:** 1R13AR078065-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** TERRY L. SHEPPARD
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $15,900
- **Award type:** 1
- **Project period:** 2020-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10070758

## Citation

> US National Institutes of Health, RePORTER application 10070758, Skin-Immune Crosstalk (1R13AR078065-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10070758. Licensed CC0.

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