# Neuronal Cell Biology: A Biology of Extremes

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2020 · $10,000

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled Neuronal Cell Biology: A Biology of
Extremes organized by Drs. Timothy A. Ryan and Erin M. Schuman. The conference will be held in Santa Fe,
New Mexico from January 23-26, 2021.
Neurons are a perfect example of the biology of extremes. Most neurons in the brain must live without dividing
for 7-9 decades of life. Individual cells cover spatial expanses that are truly enormous compared to the
molecular scale. Although cell somas of neurons are comparable in size to many other types of cells in the
body, neurons are polarized cells and the output compartment, the axon, of an individual cell in the brain can
extend up to 40 cm in a rodent and probably much further in a human, i.e. 20,000 times more than typical cells.
The molecular basis of how neurons are built and sustained at these “extremes” is a central problem in
neuronal biology. The tools needed to understand basic questions like protein and lipid synthesis and turnover
in neurons as well the metabolic basis of synaptic performance are just beginning to emerge. These properties
are all thought to be particularly impactful in diseases associated with aging, such as most neurodegenerative
diseases. As these rapid and major ongoing advances in neuronal cell biology continue, they have allowed for
a mechanistic understanding and therapeutic intervention in many neurologic diseases. This conference will
convene leaders in the field, together with trainees and emerging investigators, to address cutting-edge
advances in this rapidly evolving field.

## Key facts

- **NIH application ID:** 10070885
- **Project number:** 1R13NS118793-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** Thale Cross Jarvis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $10,000
- **Award type:** 1
- **Project period:** 2020-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10070885

## Citation

> US National Institutes of Health, RePORTER application 10070885, Neuronal Cell Biology: A Biology of Extremes (1R13NS118793-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10070885. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*