# Heart Failure: Mechanisms and Therapies

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2020 · $17,000

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled Heart Failure: Mechanisms and Therapies
organized by Drs. David A. Kass and Saptarsi M. Haldar. The conference will be held in Santa Fe, New
Mexico from January 14-18, 2021.
Heart failure (HF) is a leading global cause of morbidity and mortality. Moreover, its prevalence is increasing
exponentially as individuals live longer to experience the collusive effects of accumulated disease, genetic
propensities, environmental stressors, and behavioral factors. The underpinnings of HF are multifactorial,
providing a broad array of relevant biochemical therapeutic targets that could impact clinical symptoms and
outcomes. The impacts of aging, and the epidemic of obesity and associated disorders such as diabetes are
having a major impact on heart failure pathophysiology. This conference will particularly highlight the roles of
altered metabolism, mitochondrial dysfunction, protein quality control, inflammation, and fibrosis. The recent
explosion of methods to assess subpopulations at the single-cell level, and studies of epigenetic controls on
disease and heart development/regeneration are presented. Additionally, we are at the dawn of a new age for
manipulating contractility of the heart, and recent advances in HF treatment, including clinical testing, will be
discussed during this conference. The conference emphasizes cutting edge basic research, emphasizing
rapidly advancing areas that pave the way to new opportunities. Many of the speakers will be leaders in highly
relevant fields yet often not those one would hear at the typical HF conference. In this sense, a goal is to
encourage new dialog and interdisciplinary collaborations between fields that all have prominent roles in the
failing heart. Lastly, this conference is being paired with another Keystone Symposia conference on
Mitochondria, Metabolism and Heart, which will also have a cardiac emphasis. There will be two joint sessions
that will focus on mitochondrial function and metabolism, respectively.

## Key facts

- **NIH application ID:** 10070901
- **Project number:** 1R13HL154588-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** Thale Cross Jarvis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $17,000
- **Award type:** 1
- **Project period:** 2020-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10070901

## Citation

> US National Institutes of Health, RePORTER application 10070901, Heart Failure: Mechanisms and Therapies (1R13HL154588-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10070901. Licensed CC0.

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