# Molecular Genetics Core

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $177,047

## Abstract

Project Summary/Abstract - Molecular Genetics Core
Given the value of model organisms and molecular genetic tools for the study of diabetes and its co-
morbidities, the Molecular Genetics Core (MGC) is designed to aid diabetes researchers in the development of
novel rodent models and molecular tools to determine the cellular and molecular mechanisms contributing to
diabetes. Established in 2015, the MGC is a fee-for-service core that facilitates the application of molecular
genetic methods to diabetes-related research. Specifically, the MGC (1) designs and produces genetically-
modified rodent models (using CRISPR/Cas9) for use in diabetes-related research; (2) designs and produces
AAV vectors for use in diabetes research; (3) produces and provides specialty viral reagents for use in
diabetes research; and (4) provides advice and training in the use of these technologies to members of MDRC
laboratories. The MG Core also owns and maintains several pieces of shared equipment for the use of MDRC
members located at different sites around the UM medical campus.
While CRISPR/Cas9 technology has dramatically increased the speed and decreased the cost at which such
models can be generated, the pace at which this new technology continues to evolve prevents many diabetes
researchers from taking full advantage of its potential. The MGC fills this gap by using its expertise and
personnel to design and construct CRISPR/Cas9 targeting reagents, collaborate with the UM Transgenic Core
to test these reagents in embryos and produce founder mice, and identify founders for transfer (along with
genotyping protocols) to the MDRC investigator. For the generation of viral reagents, the MGC designs and
produces any necessary constructs, which are packaged into viruses by the UM Viral Vector Core. With input
from MDRC members and the MGC advisory committee, the MGC also identifies and develops new
technologies (viral and genetic) in support of the research programs of MDRC members.

## Key facts

- **NIH application ID:** 10071180
- **Project number:** 5P30DK020572-44
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** DAVID P OLSON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $177,047
- **Award type:** 5
- **Project period:** 1996-12-01 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10071180

## Citation

> US National Institutes of Health, RePORTER application 10071180, Molecular Genetics Core (5P30DK020572-44). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10071180. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*