# Rat Genome Database

> **NIH NIH R01** · MEDICAL COLLEGE OF WISCONSIN · 2021 · $2,135,569

## Abstract

The goal of the Rat Genome Database (RGD) is to provide a research platform that delivers the
data and tools necessary for investigators to advance preclinical and translational research.
This involves acquiring, validating and integrating comprehensive genetic, genomic, phenotype
and disease datasets for rat as well as human, mouse and other mammals used as disease
models. One hallmark of the RGD resource has been the development of innovative data
mining, presentation and analysis tools. RGD's user community has long included those using
rat as a disease model, those doing cross-organism studies particularly with mouse and human,
clinical researchers looking for models to understand the impact of genetic and environmental
variations on disease mechanisms and those using informatics and computational approaches
to analyze data. Increasingly, users are looking for access to data on precision models to
validate and replicate potential genetic and environmental factors identified through clinical
sequencing projects that may impact disease onset, progression or treatment. To support a
diverse user community, we will 1) continue to acquire, validate, analyze, and integrate genomic
data with increasing emphasis on variants, non-coding and regulatory elements for rat, human,
mouse and multiple other mammals, 2) expand functional annotations beyond disease,
phenotype, Gene Ontology, pathway and drug/chemical-gene interactions to expression,
metabolome and microbiome data along with the analyses that provide connections among
these and insight into commonalities among elements of datasets, and 3) provide quantitative
phenotype profiles and expected ranges for individual strain models and controls along with
genotype profiles with expansions to other mammals to assist researchers in identifying
appropriate models for their studies. RGD will integrate data from multiple organisms into its
tools and expand its genomic tools including the development of a comparative map tool. We
will continue to assign official nomenclature to all rat genomic elements, mapped phenotypes
and strains as part of our quality control efforts, resolve conflicts and identification for rat data
integrated from multiple sources and return corrected data to originating sources. RGD will
expand REST APIs and FTP site files to accommodate new and analyzed datasets and will
continue to support users of multiple browsers and devices.

## Key facts

- **NIH application ID:** 10071969
- **Project number:** 5R01HL064541-22
- **Recipient organization:** MEDICAL COLLEGE OF WISCONSIN
- **Principal Investigator:** ANNE E. KWITEK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,135,569
- **Award type:** 5
- **Project period:** 1999-09-30 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10071969

## Citation

> US National Institutes of Health, RePORTER application 10071969, Rat Genome Database (5R01HL064541-22). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10071969. Licensed CC0.

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