# The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

> **NIH NIH U01** · STANFORD UNIVERSITY · 2020 · $473,100

## Abstract

Project Summary/Abstract
This application to renew our participation in the Consortium for the Study of Chronic Pancreatitis,
Diabetes and Pancreas Cancer (CPDPC), will enable the Stanford Clinical Center to continue its
productive recruitment of patients into four key clinical studies of the consortium – 1) Prospective
Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED), 2)
Pediatric Longitudinal Cohort Study of Chronic Pancreatitis [The International Study Group of
Pediatric Pancreatitis: In Search for a Cure (INSPPIRE2), 3) Prospective Study to Establish a New
Onset Diabetes Cohort (NOD), and 4) Evaluation of a mixed meal test for Diagnosis and
characterization of Pancreaticogenic Diabetes secondary to pancreatic cancer and chronic
pancreatitis (DETECT). Prospectively collected specimens from these studies will be used to further
examine the role of the immune system in chronic pancreatitis and its relationship to the development
of diabetes and pancreas cancer.
In response to the research objectives of the CPDPC Consortium as outlined in this RFA, we have
formed a strong scientific team with broad complementary expertise in clinical adult and pediatric
pancreatitis, endocrinology, radiology, primary care, and immunology. Our proposal is highly
responsive to the RFA in several specific ways. As part of the original Consortium, our Clinical Center,
has demonstrated capacity to effectively recruit patients into 4 primary studies of the CPDPC. We
have successfully used archived specimens to demonstrate potential immune signals to diagnose
chronic pancreatitis and pancreatic cancer. In this renewed proposal, we intend to continue to validate
these studies using prospectively collected samples from the prospective longitudinal cohorts of this
consortium. We hope to ultimately develop and validate cytokine profiles that may facilitate diagnosis
of chronic pancreatitis, predict likelihood of associated complications, and lead to targets to support
clinical trials to halt fibrosis. For pancreas cancer, these studies may lead to novel diagnostic tests to
detect pancreatic cancer at earlier stages. The opportunity to further investigate and validate these
novel observations in collaboration with other centers remains an exciting opportunity to change
diagnosis and patient management for chronic pancreatitis and its associated complications of
pancreatogenic diabetes and pancreas cancer development.

## Key facts

- **NIH application ID:** 10072383
- **Project number:** 2U01DK108300-06
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Walter Gwang-Up Park
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $473,100
- **Award type:** 2
- **Project period:** 2015-09-28 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10072383

## Citation

> US National Institutes of Health, RePORTER application 10072383, The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (2U01DK108300-06). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10072383. Licensed CC0.

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