# Mechanistic basis of inflammation in Alzheimers Disease

> **NIH NIH R21** · OHIO STATE UNIVERSITY · 2020 · $224,264

## Abstract

Abstract
Alzheimer’s disease (AD) is a progressive inflammatory neurodegenerative disorder leading to debilitating
cognitive dysfunction, and is still without cure or effective prevention options. Several studies demonstrated
that low grade inflammation in the brain is associated with higher risk of AD. Patients with AD exhibit an
overproduction of the pro-inflammatory cytokine interleukin-1 beta (IL-1β) in the cerebrospinal fluid and brain
tissue. Importantly, exaggerated IL-1β levels robustly inhibit synaptic plasticity mechanisms critical for normal
memory function. In this application we will determine the function of members of the canonical and non-
canonical inflammasome in relation of AD.

## Key facts

- **NIH application ID:** 10072486
- **Project number:** 1R21AG064899-01A1
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** Amal O Amer
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $224,264
- **Award type:** 1
- **Project period:** 2020-09-15 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10072486

## Citation

> US National Institutes of Health, RePORTER application 10072486, Mechanistic basis of inflammation in Alzheimers Disease (1R21AG064899-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10072486. Licensed CC0.

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