# Modulating attention and decision making with closed loop control of low frequency oscillations

> **NIH NIH R01** · UNIVERSITY OF MINNESOTA · 2021 · $490,536

## Abstract

Project Summary
Synchronous low-frequency brain activity, as measured by human EEG, has been implicated in both normal
cognition and in disease states such schizophrenia. However, we still do not know whether changes in such
rhythms directly alter neuronal information processing, or are merely epiphenomenal. To address this issue, we
will measure how single and multi unit activity linked to task performance in non-human primates is altered by
endogenous alpha rhythms, and how that activity is changed when alpha rhythms are directly modulated via
closed-loop electrical stimulation. The proposal will offer a mechanistic explanation for the relationship between
alpha rhythms, attention, and perceptual decision making and validate the potential of direct modulation of alpha
rhythms as a therapeutic approach to attentional pathologies.

## Key facts

- **NIH application ID:** 10073544
- **Project number:** 5R01MH118487-03
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** GEOFFREY M GHOSE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $490,536
- **Award type:** 5
- **Project period:** 2019-03-20 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10073544

## Citation

> US National Institutes of Health, RePORTER application 10073544, Modulating attention and decision making with closed loop control of low frequency oscillations (5R01MH118487-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10073544. Licensed CC0.

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