# Maintenance and Incidence of ME/CFS following Mono

> **NIH NIH R01** · DE PAUL UNIVERSITY · 2021 · $566,965

## Abstract

Abstract
It is unclear which psychological and biological variables are potential maintenance factors for ME/CFS
following IM because few prospective studies have collected baseline data before the onset of IM and then
followed these subjects prospectively following the diagnosis of ME/CFS. In our currently funded NIH study,
the focus has been on pre-illness clinical and biological predictors of ME/CFS development following IM in a
diverse group of college students. General screens of health and psychological well-being, as well as blood,
were obtained at all three stages of the study (Stage 1 - when the students are well; Stage 2 – at the time they
are acutely ill with IM, Stage 3 – six months after IM, when they have either developed ME/CFS or recovered).
Wave 1 refers to data we are currently collecting and Wave 2 will be funded by the proposed grant and
involves a five-year follow-up with the original Wave 1 subjects. Cohort 1 includes those college students who
developed IM during Wave 1, and preliminary data indicate that these students showed marked differences at
baseline from those who did not develop ME/CFS 6 months following IM. Cohort 2 includes those who did not
develop IM in Wave 1. We expect some of these subjects will develop ME/CFS over time. Our study will
assess both clinical and biological maintenance factors for of ME/CFS following IM, and determine
prospectively the incidence of ME/CFS in a sample of young adults.

## Key facts

- **NIH application ID:** 10073555
- **Project number:** 5R01NS111105-02
- **Recipient organization:** DE PAUL UNIVERSITY
- **Principal Investigator:** Leonard A Jason
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $566,965
- **Award type:** 5
- **Project period:** 2020-01-01 → 2024-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10073555

## Citation

> US National Institutes of Health, RePORTER application 10073555, Maintenance and Incidence of ME/CFS following Mono (5R01NS111105-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10073555. Licensed CC0.

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