# The Texas-Louisiana Alliance to Study Chronic Pancreatitis, Diabetes and Pancreatic Cancer

> **NIH NIH U01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $468,829

## Abstract

PROJECT SUMMARY/ABSTRACT
Our proposal is in keeping with the objectives of the RFA to continue the excellent ongoing studies of the
consortium (CPDPC) to study the relationship between Chronic Pancreatitis (CP), Diabetes (DM) and Pancreatic
Cancer (PDAC). The Principal Investigators of this proposal (Drs. Chari and Maitra, both currently based at UT
MD Anderson Cancer Center, UTMDACC) have played key and substantial roles in the first cycle of the CPDPC.
First, they have served as co-leaders of the DM-PDAC working group, which has been responsible for the design
and conduct of the ongoing NOD study, which was inspired by a series of seminal observations made by Dr.
Chari in the 2000s. Second, Dr. Maitra has served as Co-PI of the Data Management and Coordination Center
(DMCC) of the CPDPC, which provides him with extensive familiarity with the inner workings of data
management and oversight required for accrual to NOD and other prospective cohorts. Third, Dr. Chari was
previously the site Co-PI of Mayo Clinic site, which has contributed to all aspects of CPDPC in the last cycle.
From the experience of the past 4.5 years, it is clear that successful recruitment of subjects to these studies
requires a mix of tertiary care hospitals (for PROCEED and DETECT cohorts), combined with access to large
primary care healthcare systems with integrated electronic medical record systems, information technology (IT)
support and infrastructure (for the NOD study). To this end, an Alliance of Texas and Louisiana investigators and
institutions overseen by the PIs at UTMDACC will recruit to ongoing CPDPC cohort studies. In addition, we
propose 6 ancillary studies that are ideally suited for performance by a collaborative consortium and significantly
advance our understanding of the interconnected pathologies of CP, PDAC and DM. In accordance with the
RFA, the Specific Aims of our proposal are to: Aim 1 a) Recruit subjects for PROCEED study: This will occur at
the University of Texas Health Sciences Center, Houston (UTHSC-H) and Memorial Hermann Health System,
both large volume gastroenterology practices that are well positioned to recruit patients for the PROCEED Study.
b) Recruit subjects for the DETECT study: The UTHSC-H will recruit patients for DETECT study c) Recruit
subjects for the NOD Study: The recruitment will occur through the Ochsner Clinic, Louisiana, a large, integrated
primary health system in Louisiana, which is also highly enriched for underrepresented minority population of
African Americans, who are known to harbor a preponderance of both DM and PDAC. Aim 2) Perform a series
of innovative ancillary studies to examine the association among CP, DM and PDAC: 6 such studies are outlined
in this proposal.

## Key facts

- **NIH application ID:** 10073607
- **Project number:** 1U01DK126365-01
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** SURESH T. CHARI
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $468,829
- **Award type:** 1
- **Project period:** 2020-09-05 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10073607

## Citation

> US National Institutes of Health, RePORTER application 10073607, The Texas-Louisiana Alliance to Study Chronic Pancreatitis, Diabetes and Pancreatic Cancer (1U01DK126365-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10073607. Licensed CC0.

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