# Laboratory and Analytical Core

> **NIH NIH U54** · YALE UNIVERSITY · 2020 · $219,546

## Abstract

ABSTRACT – LABORATORY AND ANALYTICAL CORE
The proposed projects of this application are concerned with reducing tobacco addiction through better
understanding of how flavors and sweeteners influence behavior and addiction related to nicotine and tobacco.
Research strategies include administration, by various routes, of nicotine alone, and nicotine in conjunction
with other constituents, including menthol, flavors and sweeteners, followed by assessments of responses to
nicotine. Optimal interpretation of study outcomes requires that variations in exposures to nicotine and/or flavor
and sweetener constituents across individuals and experimental arms are considered. The primary objectives
of the analytical laboratory core will therefore be to: 1) accurately identify and measure nicotine, flavors and
sweeteners in tobacco products, and vapors produced from them; and 2) to provide objective estimates of
exposures to such products by quantifying levels of nicotine, nicotine metabolites, and other constituents in
biological fluids. The core will directly support all three projects and pilots of this proposal and will also be
available to other tobacco research centers, including Rapid Response Projects announced by the FDA-CTP,
on a cost reimbursement basis. Furthermore, the core will be able to set up other assays as mandated by the
evolving needs of the center. To facilitate collaborations across other tobacco research centers, the core will
generate a database of selected tobacco product constituents and biomarkers of exposure. Finally, all
biological samples obtained in this Center will be maintained on site, in a frozen sample repository. The core
will be led by Dr. Julie Zimmerman, who has considerable experience with chemical analysis of tobacco
products, and Dr. Tore Eid, a clinical pathologist and neuroscientist who directed the core laboratory of the
current NIH-funded Yale Tobacco Center of Regulatory Science (TCORS), and is an expert in chemical
analysis of biological samples.

## Key facts

- **NIH application ID:** 10073638
- **Project number:** 3U54DA036151-07S1
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** TORE EID
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $219,546
- **Award type:** 3
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10073638

## Citation

> US National Institutes of Health, RePORTER application 10073638, Laboratory and Analytical Core (3U54DA036151-07S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10073638. Licensed CC0.

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