# SWOG Biospecimen Bank to Support NCI NCTN

> **NIH NIH U24** · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2020 · $2,048,483

## Abstract

Project Summary
SWOG is an adult clinical trials cancer group within the National Clinical Trials Network (NCTN) of the National
Cancer Institute (NCI). SWOG clinical trials include a range of cancer types (e.g., breast, lung, colon, prostate,
leukemia, melanoma, lymphoma, and multiple myeloma). The SWOG Biospecimen Bank (Biobank), located in
the Biopathology Center (part of the Abigail Wexner Research Institute of Nationwide Children's Hospital), was
designed to procure, process, bank, and distribute biospecimens collected as a major component of NCI-
sponsored clinical trials. These biospecimens are linked to demographic information, surgical and pathological
reports, and treatment and follow-up data of study participants enrolled on SWOG protocols. Upon review and
approval, biospecimens are prioritized for distribution to the specific SWOG investigators defined in the clinical
trial protocols. After the needs of the planned research have been addressed, residual (legacy) banked
biospecimens can be distributed to other investigators within and outside SWOG via the NCTN Navigator. The
SWOG Group and Biobank Concierges can also facilitate access to SWOG legacy biospecimens that are not
currently uploaded in Navigator. This process has been designed to mirror the process for legacy
biospecimens on the Navigator system and includes a feasibility assessment by the SWOG Biobank and the
SWOG Statistical and Data Management Center prior to proposal submission. The Biobank is a functioning
and viable part of SWOG's clinical and translational medicine program, and focuses on the integration of
diagnostic, therapeutic, laboratory, and clinical data to answer questions in clinical and translational research.
The SWOG Biobank works under the hypothesis that banking of high quality, clinically-annotated and cancer-
related human biospecimens, linked to molecular signatures/markers, will significantly facilitate and further
advance clinical cancer research. To support this effort, the SWOG Biobank manages these biospecimens
under strict guidelines and standard operating procedures based on current Best Practices for biorepositories
and the latest laboratory technologies. The Biobank's experience, coupled with a firm commitment to quality
and integrity operations, makes it uniquely able to provide an accurate and effective resource of tumor and
normal samples with associated clinical, epidemiologic, and protected health information. The SWOG Biobank
aims to harmonize and expand general banking practices and innovative technologies, which will continue to
facilitate molecular biology research and increase investigator participation in clinical research trials via the
NCI-sponsored Group Banking Committee (GBC). The SWOG Biobank also plans to support the processing,
banking, and distribution of biospecimens to the Cancer Immune Monitoring and Analysis Centers (CIMACs).

## Key facts

- **NIH application ID:** 10074045
- **Project number:** 2U24CA196175-06
- **Recipient organization:** RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- **Principal Investigator:** NILSA DEL CARMEN RAMIREZ MILAN
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,048,483
- **Award type:** 2
- **Project period:** 2015-04-23 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10074045

## Citation

> US National Institutes of Health, RePORTER application 10074045, SWOG Biospecimen Bank to Support NCI NCTN (2U24CA196175-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10074045. Licensed CC0.

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