# Diabetes Models Phenotyping

> **NIH NIH P30** · WASHINGTON UNIVERSITY · 2021 · $137,251

## Abstract

ABSTRACT: Diabetes Models Phenotyping Core 
The Diabetes Models Phenotyping Core of the Washington University Diabetes Research Center (DRC) has a 
long-term goal of enhancing diabetes-related research at Washington University through the use of 
sophisticated services and technologies likely to contribute to discoveries that can be translated to novel 
treatments for diabetes and its complications. The three objectives of the Core are: 1) To provide phenotyping 
services to DRC members in order to facilitate NIH-funded diabetes/metabolism-related research and enhance 
the cost-effectiveness of that research; 2) To train DRC investigators in the maintenance and manipulation of 
mouse colonies relevant to diabetes and metabolic research; and 3) To develop new research capabilities to 
enhance the ability of DRC members to perform diabetes and metabolic research. The Core fulfills an 
important need in the diabetes research community with 52 DRC investigators utilizing services during the past 
funding period. Over this time frame, the Core provided extensive support that included more than 7,000 
biochemical assays of serum, more than 4,400 determinations of mouse body composition, and more than 
1,000 indirect calorimetry assessments in mice, to mention the services in greatest demand. Evidence of 
considerable Core evolution include: elimination of some services, institution of better defined quality control, 
expanded training to include rigorous approaches to normalizing energy balance and other issues (all in 
response to criticisms at the time of the last competitive renewal), addition of new instrumentation, upgrades to 
existing instrumentation, increased physical size of the Core, and improved operational flow. Over this current 
project period, Diabetes Models Phenotyping Core support helped users contribute a series of important 
scholarly advances with substantial potential for translation to improved care for people with diabetes.

## Key facts

- **NIH application ID:** 10075909
- **Project number:** 5P30DK020579-44
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Clay F. Semenkovich
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $137,251
- **Award type:** 5
- **Project period:** 1996-12-01 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10075909

## Citation

> US National Institutes of Health, RePORTER application 10075909, Diabetes Models Phenotyping (5P30DK020579-44). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10075909. Licensed CC0.

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