# The Southern California Research Center for ALPD and Cirrhosis

> **NIH NIH P50** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $1,453,008

## Abstract

ABSTRACT
Alcoholic liver and pancreatic diseases (ALPD) and cirrhosis constitute leading life-style diseases caused by
alcohol abuse around the globe. The Southern California Research Center for ALPD and Cirrhosis unifies 58
investigators from seven academic institutions in Southern California to pursue a common mission of being a
leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted
its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular
mechanisms underlying ALPD and cirrhosis. These efforts culminated to groundbreaking discoveries on
molecular mechanisms and therapeutic targets of the diseases. The center’s interactive environment and
infrastructure have facilitated in the past 5 years, a 187% increase in research base to $16.3M/year; 13 new
U01/P01 programs; 219 publications; generation of 12 NIH-funded early-stage investigators; 8 of 15 postdocs
transitioned to faculty positions pursuing research at the center; training 179 graduate and 38 undergraduate
students; and organizing 2 community seminars and 4 international symposia. As a unique national resource,
the center has supported 34 non-center member investigators; 13 of whom via provision of animal model
services of the Animal Core; and 27 of whom via the Core’s Tissue Sharing Program, facilitating 13
publications and 15 grant acquisitions and applications by these investigators.
 The center will continue to strive as a unique scientific center of excellence in ALPD and cirrhosis by: 1)
maximizing our interactive and synergistic environment for a pursuit for the center’s main research theme:
identification of therapeutic targets for advanced ALPD and cirrhosis;
2) serving as a national and international resource in our fields of research via provision of unique models,
technology and expertise, as well as collaborations with outside investigators including NIAAA-funded
scientists;
3) providing comprehensive education and research training at the multi-levels ranging from undergraduate
and graduate students, postdoctoral trainees, to junior scientists and faculty in order to foster and support
future generations of independent scientists in the ALPD and cirrhosis field; and
4) continuing outreach efforts to disseminate the center’s new findings to lay public, healthcare workers, and
scientists in our home and global communities.

## Key facts

- **NIH application ID:** 10077252
- **Project number:** 5P50AA011999-23
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** HIDEKAZU TSUKAMOTO
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,453,008
- **Award type:** 5
- **Project period:** 1999-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10077252

## Citation

> US National Institutes of Health, RePORTER application 10077252, The Southern California Research Center for ALPD and Cirrhosis (5P50AA011999-23). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10077252. Licensed CC0.

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