# The role of NLRP6 and DHX15 in control of infection by RNA viruses

> **NIH NIH R01** · YALE UNIVERSITY · 2021 · $418,750

## Abstract

ABSTRACT
 Pattern recognition receptors sense pathogen-associated molecular patterns and mediate the
earliest host innate immune response to infection. The cytosolic nucleotide oligomerization domain
(NOD) like receptors (NLRs) are a highly conserved group of cytosolic proteins that play a central role in
the immune response to diverse microorganisms, environmental insults and cellular danger signals. We
have recently demonstrated a role for Nlrp6 in the control of enteric virus infection. Nlrp6 controls enteric
virus infection in the intestine by interacting with a RNA sensor, Dhx15. Here we propose to define the
mechanisms of NLRP6-mediated anti-viral pathways, to identify whether other helicases may also
interact with NLRP6 (Aim 1), whether other relevant RNA viruses are recognized through this pathway,
and whether mutations may underlie certain human cases of vaccine failures (Aim 2). A fuller
understanding of the triggers and physiologic function and signaling pathways for NLRs will provide key
insights to immune mechanisms involved in host defense and immune-mediated diseases.

## Key facts

- **NIH application ID:** 10077531
- **Project number:** 5R01AI127865-04
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Erol Fikrig
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $418,750
- **Award type:** 5
- **Project period:** 2018-01-01 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10077531

## Citation

> US National Institutes of Health, RePORTER application 10077531, The role of NLRP6 and DHX15 in control of infection by RNA viruses (5R01AI127865-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10077531. Licensed CC0.

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