# OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-up

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $196,802

## Abstract

Project Summary
 The “Ocular Hypertension Treatment Study (OHTS 3): 20-year follow-up (Phase 3)” was
designed to determine the incidence and severity of primary open angle glaucoma (POAG) in
the longstanding OHTS cohort. and determine the frequency and severity of functional
limitations associated with POAG. Moreover, this well-characterized cohort has precise
information on the dates/timing of the development of POAG assessed by 3 glaucoma specialist
endpoint committee members, as well as extensive data on self-reported functional limitations of
its participants. Spectral domain optical coherence tomography (OCT), now the standard of care
for detecting glaucomatous structural damage and change was included for the first time in
OHTS as part of the OHTS 3 core visit.
 The objective of this secondary data analysis proposal is to analyze the OHTS 3 OCT
scans and leverage the 20 years of OHTS data to provide guidance on how best to utilize OCT
in the clinical management of glaucoma. Specific Aim 1 will determine whether review of macula
scans improves POAG detection compared to the clinical standard review of VF and RNFL
scans. With the increased focus on patient-reported outcomes as a key measure of treatment
success, in Specific Aim 2 we will utilize the extensive quality of life (QOL) surveys from OHTS
3 and include OCT structural damage in models to predict functional limitations due to POAG.
Finally, with a participant median age of 73 years at the OHTS 3 core visit, Specific Aim 3 will
characterize structural damage and its determinants 10 and 15 years after the precise onset of
POAG and compare it to age-related structural changes in these older subjects who did not
develop POAG.

## Key facts

- **NIH application ID:** 10077563
- **Project number:** 5R21EY031125-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** LINDA M ZANGWILL
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $196,802
- **Award type:** 5
- **Project period:** 2020-01-01 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10077563

## Citation

> US National Institutes of Health, RePORTER application 10077563, OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-up (5R21EY031125-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10077563. Licensed CC0.

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