# Pediatric Heart Network Prairieland Consortium

> **NIH NIH UG1** · CINCINNATI CHILDRENS HOSP MED CTR · 2021 · $343,199

## Abstract

Project summary
This competing renewal application aims to demonstrate that the Prairieland Consortium (PC) has the patient
population, faculty and staff expertise, clinical services, research resources, and enrollment and follow-up
successes to continue as an outstanding and productive member of the NHLBI’s Pediatric Heart Network. The
PC is unique in that it is comprised of two pediatric cardiovascular programs located at Cincinnati Children’s
Hospital Medical Center (CCHMC) in Cincinnati, OH, and Riley Hospital for Children (RHC), in Indianapolis, IN.
This consortium is led by an established collaboration between Dr. James F. Cnota at the University of
Cincinnati College of Medicine, and Dr. R. Mark Payne at Indiana University School of Medicine. Together, the
institutions are responsible for more than 1,000 cardiothoracic surgeries, >14,000 patient visits, and >20,000
in-house echocardiograms per year. Unique features of this collaboration include a large and diverse
population in the heartland of America for recruitment and enrollment into clinical studies, strong CTSA’s at
both institutions supporting the infrastructure, excellent and collaborative clinical research coordinator teams,
established and robust bioinformatics infrastructures, and meaningful integration of clinical cardiology, basic
science, and surgical services at both sites. In Aim 1, we will utilize our pediatric and ACHD clinics to recruit
and enroll subjects into approved PHN protocols, and support long-term cohort follow-up. We will pursue high
enrollment rates, and collect patient data and samples per approved protocols. We will rapidly enter de-
identified electronic data and deliver biological samples to PHN repositories to meet Network goals and
standards. In Aim 2, we will develop and implement research protocols for clinical and translational trials. Our 2
centers will continue to hold frequent scheduled videoconferences and in-person meetings to generate new
ideas, data, and protocols for submission to the NIH and PHN for consideration. In particular, we will include
our strong cardiovascular genetic and basic science colleagues in these discussions to develop new clinical
and translational protocols. We will utilize our respective CTSA’s to help develop and pilot preliminary studies
that will be used to generate full protocols for submission to the PHN. We will continue actively to participate in
PHN meetings and committees, protocol review and development, industry and NIH sponsored trials, and
educational missions of the PHN. The long-term goal of our participation in the PHN is to advance the care and
understanding of children with congenital and acquired heart disease. The Prairieland Consortium is eager to
continue its collaboration with other clinical centers, the data-coordinating center (NERI), the NHLBI staff, and
industry partners to complete ongoing studies and initiate innovative new investigations.

## Key facts

- **NIH application ID:** 10078967
- **Project number:** 5UG1HL135678-05
- **Recipient organization:** CINCINNATI CHILDRENS HOSP MED CTR
- **Principal Investigator:** James Cnota
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $343,199
- **Award type:** 5
- **Project period:** 2017-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10078967

## Citation

> US National Institutes of Health, RePORTER application 10078967, Pediatric Heart Network Prairieland Consortium (5UG1HL135678-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10078967. Licensed CC0.

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