# 6 month extension in the Pediatric Preclinical Testing Consortium (PPTC) Coordinating Center (PPTC-CC) 1U01CA199222-01

> **NIH NIH U01** · RESEARCH TRIANGLE INSTITUTE · 2020 · $249,646

## Abstract

The main goal of the Pediatric Preclinical Testing Consortium (PPTC) is to develop models that will
translate to human clinical practice and effectively prioritize therapies for the treatment of pediatric
cancers. An effective Coordinating Center (CC) will be critical to the Consortium’s goals by providing
broad organizational, scientific, and analytic expertise to support NCI scientists and the PPTC Research
Programs. The CC will also be responsible for developing, implementing, and evaluating a
comprehensive PPTC research program, providing leadership in data collection and ongoing program
evaluation to ensure that the research program is making optimal progress toward the PPTC mission.
Providing the organizational and administrative leadership necessary to enable the Consortium to
function efficiently will also be a key function of the CC. RTI’s goal as the proposed CC for the PPTC will
be to optimize Consortium progress in generating reliable data to accelerate the development of more
effective treatments for children with cancer by achieving the following specific aims:
1. Guide interactions between Consortium members and the pediatric oncology community. Provide the
logistical support necessary to run an efficient and productive Consortium through effective
teleconferences, webinars, Consortium meetings, and website. Employ these tools to facilitate
interactions between PPTC members, pharmaceutical companies, and pediatric oncology advocacy
organizations to ensure that promising new therapies are utilized efficiently.
2. Generate reliable predictive data that can be used for prioritization of therapeutic agents in pediatric
cancer. Provide efficient and robust procedures for data collection, and statistical analysis of data
collected from the Research Programs.
3. Provide the Consortium with a comprehensive, yet flexible set of scientific, statistical, and analytic
resources needed to develop an innovative research program for creating a functional Consortium for
pediatric preclinical testing. Develop tools to track the status of each potential drug candidate through
the preclinical process. Document variables in a Consortium-side data dictionary as one element to build
the data management system in REDCap.

## Key facts

- **NIH application ID:** 10081216
- **Project number:** 3U01CA199222-05S1
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** GREGORY J GATTO
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $249,646
- **Award type:** 3
- **Project period:** 2020-05-01 → 2020-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10081216

## Citation

> US National Institutes of Health, RePORTER application 10081216, 6 month extension in the Pediatric Preclinical Testing Consortium (PPTC) Coordinating Center (PPTC-CC) 1U01CA199222-01 (3U01CA199222-05S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10081216. Licensed CC0.

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