# Portable Noninvasive Positive Airway Device for COPD Patient Therapy

> **NIH NIH R44** · KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT · 2020 · $251,772

## Abstract

Abstract
Koronis Biomedical Technologies proposes to develop and fully evaluate a novel, on-demand handheld bi-level
positive airway pressure (BiPAP) ventilator to treat Chronic Obstructive Pulmonary Disease (COPD) patients
suffering from exertional dyspnea (“breathlessness”). It is well known that dyspnea trends severe COPD
patients as they age towards inactivity, resulting in peripheral muscle deconditioning that further increases the
risk of experiencing dyspnea, establishing a vicious cycle of recurrent fear of dyspnea, further inactivity and
potential social isolation. The proposed Bi-level Rapid Emergency Airway THErapy (BREATHE) system will be
optimized to provide proven BiPAP therapy to rapidly relieve acute dyspnea in a miniaturized, portable
handheld form factor. This system will allow for therapy on the go, untethering the patient and increasing their
confidence to engage in activities of daily living.

## Key facts

- **NIH application ID:** 10081908
- **Project number:** 1R44HL154932-01
- **Recipient organization:** KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
- **Principal Investigator:** Robert J Knuesel
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $251,772
- **Award type:** 1
- **Project period:** 2020-08-15 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10081908

## Citation

> US National Institutes of Health, RePORTER application 10081908, Portable Noninvasive Positive Airway Device for COPD Patient Therapy (1R44HL154932-01). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10081908. Licensed CC0.

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