# A Comprehensive Data-driven Platform for Acute Ischemic Stroke Patient Outcomes

> **NIH NIH R43** · NESTED KNOWLEDGE, INC · 2020 · $196,161

## Abstract

PROJECT SUMMARY
A wide range of vital decisions, from reimbursement to regulatory clearance to physician and patient decision-
making, depend on clinical publication. Clinical publications are the primary mechanism of evidence-based
decisions, and literature reviews are thus the primary comprehensive clinical outcome comparison
methodology. However, current literature review methods are outdated, unstructured, and disorganized, and
potentially lifesaving data are accessible and comparable only with hundreds of hours of work in literature
reviewing. Especially given the growth of technology-driven data management, the current paradigm of
combining clinical outcome data fundamentally fails to communicate to general medical audiences whether any
given therapy works, in transparent, comprehensive, and updatable forms, and the typical meta-analysis is
unable to even demonstrate level of coverage of its search across existing indices.
This problem has been recognized by many organizations, from the NIH’s Data Informatics Working Group
(DIWG) to the AAAS to The National Academies of Sciences, Engineering, Medicine, which have all publicly
stated that tech-driven harmonization and data visualization are necessary to effectively share research.
However, searchability, visualization, and harmonization efforts have not yet permeated medical publishing.
The DIWG stated that: “The colossal changes in technologies and methods for doing biomedical research have
shifted the bottleneck in science productivity from data production to data management, communication, and
data interpretation.” We agree that the greatest bottleneck in clinical sciences are in fact related to
communication, and we believe that it is due to insufficient adoption of novel technologies in publishing,
especially interactive visual methods of presenting field-wide data and automated methods of data gathering.
Our vision is to create a comprehensively researched, constantly updated, easily digestible platform for
dissemination of crucial data presented among scientific publications based on expert-designed, automated
data extraction from existing publications. After debuting in stroke—because of our previous experience in the
field—we have achieved proof-of-concept for interactive, visual meta-analyses and for partially-automated data
extraction from PDFs. Now, we propose to automate the foundation of meta-analysis, the search/inclusion
process, through data analytics and prediction modelling, and expand our platform to include all studies
relevant to stroke research. If successful, our project would provide a field-wide research tool in stroke, as well
as enabling us to create the methods that make scaling across all medical disciplines possible.

## Key facts

- **NIH application ID:** 10081942
- **Project number:** 1R43LM013501-01
- **Recipient organization:** NESTED KNOWLEDGE, INC
- **Principal Investigator:** Kevin Kallmes
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $196,161
- **Award type:** 1
- **Project period:** 2020-08-01 → 2021-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10081942

## Citation

> US National Institutes of Health, RePORTER application 10081942, A Comprehensive Data-driven Platform for Acute Ischemic Stroke Patient Outcomes (1R43LM013501-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10081942. Licensed CC0.

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