# Assays and kits for MSC-derived extracellular vesicles

> **NIH NIH R44** · CELLARCUS BIOSCIENCES INC · 2020 · $755,409

## Abstract

Abstract
All cells release small extracellular vesicles (EVs) that can carry cargo to other cells to affect
their function. Mesenchymal stromal cells (MSCs) release EVs that have regenerative activities
in vitro and in vivo and which represent potentially valuable new therapeutics. The realization of
this potential is hindered by a lack of analytical methods to characterize MSC EVs, determine
their mechanisms of action, and establish potency and dosage criteria. We will produce high
resolution analysis tools for MSC EVs that will address these limitations and enable their
development as new therapeutic entities.

## Key facts

- **NIH application ID:** 10082060
- **Project number:** 1R44GM136165-01A1
- **Recipient organization:** CELLARCUS BIOSCIENCES INC
- **Principal Investigator:** JOHN P NOLAN
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $755,409
- **Award type:** 1
- **Project period:** 2020-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10082060

## Citation

> US National Institutes of Health, RePORTER application 10082060, Assays and kits for MSC-derived extracellular vesicles (1R44GM136165-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10082060. Licensed CC0.

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