# Evaluating the Feasibility and Acceptability of a Latino MSM Focused PrEP Uptake Intervention

> **NIH NIH R34** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $227,931

## Abstract

PROJECT ABSTRACT: HIV disparity persist among Latino men who have sex with men (MSM), especially
those who are immigrants. The CDC estimates the lifetime HIV risk is 1 in 5 for Latino MSM compared to 1 in
11 for white MSM. Pre-Exposure Prophylaxis (PrEP) is a biomedical strategy highly effective in preventing HIV
acquisition, with the potential to reduce the number of new HIV infections among Latino MSM in the U.S. PrEP
involves once daily dosing of medications. The FDA has approved two medications, sold under the brand
names Truvada® and Descovy® for daily use as PrEP. The Centers for Disease Control and Prevention
(CDC) has established clinical guidelines for administering PrEP to high-risk candidates. While evidence
indicates that PrEP use is rising in the U.S., disparities persist in uptake among Latino MSM, despite their
reported high levels of interest in using PrEP. To address this disparity, we propose a 2-phase project to
develop a pilot PrEP intervention called Estoy PrEParado (I'm PrEPared) to facilitate initiation and adherence
to PrEP among immigrant Latino MSM. The project will develop an engaging, culturally tailored intervention
using the Information-Motivation-Behavioral Skills (IMB) model. The specific aims of the project are: Aim 1:
based on data from a prior study, the project will elicit feedback, validation and modification to the initial
content areas of the Estoy PrEParado intervention to facilitate PrEP adoption and adherence among immigrant
Latino MSM; and Aim 2: the project will conduct a small randomized pilot of Estoy PrEParado to assess the
feasibility, acceptability and preliminary impact of the intervention in moving immigrant Latino MSM along the
PrEP cascade to initiation. In formative phase 1, the project will use the innovative and novel World Café
approach to facilitate a community conversation with immigrant LMSM (n≈40) to validate, modify and refine the
initial intervention content areas of the Estoy PrEParado pilot intervention. The World Café is a powerful
conversational process for facilitating constructive group dialogue that produces ideas and knowledge that can
be put into practice. The project will also elicit feedback and input on the contents of the intervention from a
project-specific Intervention Advisory Committee (IAC) comprised of academic and community experts. In
phase 2, the project will conduct a small randomized pilot of 80 participants (40 participants receiving the PrEP
intervention and 40 participants receiving standard care, i.e., PrEP referrals) to establish feasibility,
acceptability and preliminary impact. If the intervention shows promise, the findings will support the preparation
of a larger scale R01 efficacy trial.

## Key facts

- **NIH application ID:** 10083014
- **Project number:** 1R34MH121228-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Ronald Andrew Brooks
- **Activity code:** R34 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $227,931
- **Award type:** 1
- **Project period:** 2020-08-15 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10083014

## Citation

> US National Institutes of Health, RePORTER application 10083014, Evaluating the Feasibility and Acceptability of a Latino MSM Focused PrEP Uptake Intervention (1R34MH121228-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10083014. Licensed CC0.

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