# Husbandry and Management Core

> **NIH NIH U42** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $144,702

## Abstract

PROJECT SUMMARY, Core A: Husbandry and Management Core
The U42 SPF 4 Rhesus macaque breeding colony for AIDS research produces MHC class-1 typed rhesus
macaques (Macaca mulatta) who are negative to simian immunodeficiency virus (SIV), simian T-lymphotropic
virus (STLV-1), simian retrovirus (type D restrovirus or SRV), and macacine herpesvirus-1 (BV). SPF4 Indian
origin rhesus macaques are the premier animal model for HIV/AIDS research, including studies of HIV
pathogenesis, AIDS-related opportunistic infections, and the development of HIV treatments and vaccines.
Demand for this resource continues to grow, and is projected to increase over the grant cycle. A predictable
supply of disease-free, genetically characterized nonhuman primates is critical in the fight against HIV/AIDs.
The overall aim of the Husbandry and Management Core is to maintain the ONPRC Specific Pathogen Free
(SPF) rhesus macaque breeding colony for AIDS research at a targeted population of 175 adult breeder
females capable of producing at least 120 surplus animals annually for research use. To achieve this we will
provide innovative team based management practices including new social monitoring strategies, a weight
management program for at-risk infants, serologic assays for Mycobacterium tuberculosis screening, and
introduction of an artificial insemination program to expand genetic diversity.

## Key facts

- **NIH application ID:** 10083096
- **Project number:** 2U42OD010426-19
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Kamm Prongay
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $144,702
- **Award type:** 2
- **Project period:** 2013-01-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10083096

## Citation

> US National Institutes of Health, RePORTER application 10083096, Husbandry and Management Core (2U42OD010426-19). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10083096. Licensed CC0.

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