# MHC Genetic Typing Core

> **NIH NIH U42** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $178,889

## Abstract

PROJECT SUMMARY, Core C: MHC Genetic Typing Core
Genetically well-characterized animal models are critical for the success of S/HIV research, including
characterization for MHC genotype, known ancestry, and pedigree relationships. In particular, informative and
accurate MHC genotyping is essential, due to the complexity of the MHC class I loci in macaques, and the
influence of allele type on disease progression. The need for genetically well-characterized animal models for
research must also be balanced against the need to preserve genetic diversity in animal colonies dedicated to
supporting biomedical research. This is a requirement not only to ensure long-term colony health, but to ensure
the relevance of experimental findings to human disease. The ONPRC is a leader in the development of many of
the current recommended approaches and technologies used in genetic typing and management of NHP
colonies. Thus, the aims of the Genetics Core for this project are to, 1) use state-of-the-art genetic testing to
characterize all ONPRC Indian-origin rhesus macaques for MHC genotype, and 2) to maximize the genetic
diversity of the ONPRC breeding colony while producing sufficient numbers of MHC-genotyped Indian-origin
rhesus macaques to meet research needs. To achieve these aims, we will conduct MHC Class I genotyping of an
additional 1,760 SPF4 Indian-origin rhesus macaques to support continued research, and will additionally
develop new or improved approaches to the genetic management of these macaques. These innovations include
the use of cost-effective genome-wide sparse sequencing to assess pedigree relationships, genetic diversity, and
ancestry in a single, combined assay; the implementation of automated, periodic reporting aimed at summarizing
genetic diversity for every breeding group in the colony; and improved algorithms for estimating the genetic value
of individual animals by adding information on demographics, genotypes or phenotypes of interest, and animal
assignment history.

## Key facts

- **NIH application ID:** 10083098
- **Project number:** 2U42OD010426-19
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Amanda Vinson
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $178,889
- **Award type:** 2
- **Project period:** 2013-01-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10083098

## Citation

> US National Institutes of Health, RePORTER application 10083098, MHC Genetic Typing Core (2U42OD010426-19). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10083098. Licensed CC0.

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