# Th9 cells in immediate hypersensitivity

> **NIH NIH R01** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $393,750

## Abstract

PROJECT SUMMARY / ABSTRACT – Th9 cells in immediate hypersensitivity
 T helper subsets regulate inflammatory diseases, including the development of allergic lung
inflammation associated with asthma. The development of T helper subsets in controlled by a network of
transcription factors that promote the expression of cytokines and other genes associated with the ability of a T
helper cell to promote disease. This proposal focuses on the most recently identified subset of T helper cells,
Th9 cells that differentiate in response to TGF and IL-4. In our preliminary data we have identified a
requirement for Th9 cells for mast cell accumulation and function in allergic airway inflammation. Interestingly,
we have identified a role for Th9 cells in facilitating immediate hypersensitivity responses. In the two Aims in
this proposal we address basic questions that are critical for understanding Th9-dependent mast cell activity. In
the first aim we will define the requirement for Th9 cells in immediate hypersensitivity using allergen
sensitization and passive transfer models of IgE-dependent mast cell function. In the second Aim we will
determine how Th9 cells regulate mast cell accumulation and activation, and determine which aspect is
required for Th9-dependent mast cell function. Together, these Aims will define new mechanisms involved in
Th9-dependent acute allergen responses. These Aims will elucidate new pathways in acute and chronic
allergic responses and highlight potentially new pathways for intervention.

## Key facts

- **NIH application ID:** 10083170
- **Project number:** 5R01AI129241-05
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** MARK H KAPLAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $393,750
- **Award type:** 5
- **Project period:** 2017-01-01 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10083170

## Citation

> US National Institutes of Health, RePORTER application 10083170, Th9 cells in immediate hypersensitivity (5R01AI129241-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10083170. Licensed CC0.

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