# Hospital-Associated Respiratory Virus Infections: Molecular Epidemiology, Clinical Outcomes, and Cost-Effectiveness of Interventions

> **NIH NIH K01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $106,212

## Abstract

PROJECT SUMMARY / ABSTRACT
Hospital-associated respiratory virus infections (HA-RVI) lead to increased morbidity, mortality, and healthcare
costs, but these infections are often under- or misdiagnosed particularly for respiratory viruses other than
influenza. HA-RVI are preventable through appropriate treatment and infection control measures, but
incomplete diagnosis leads to missed opportunities for intervention. Taking advantage of these opportunities
for intervention might require additional diagnostic testing and expanded infection control measures. The
degree to which these approaches would be cost-effective is unclear. Therefore, there is a need to define the
burden and clinical impact of respiratory viruses in the hospital setting to inform optimal diagnostic, treatment
and infection prevention strategies. The overall objective of this project is to support Josh Petrie, PhD in the
development of expertise in healthcare epidemiology, state-of-the-art molecular methods, and advanced
modeling techniques. This objective will be completed through focused training and career development
activities in healthcare epidemiology, next generation sequencing, bioinformatics, cost-effectiveness analysis,
and mathematical modeling that is overseen by an excellent team of mentors. The skills developed by the
training and career development objectives will be strengthened by mentored research to accomplish the
following Specific Aims: (1) Define the epidemiology and burden of community-acquired and hospital-
associated respiratory virus infections and compare clinical impact by viral species; (2) Improve the sensitivity
and specificity of case definitions to identify hospital-associated influenza cases by integrating clinical,
epidemiologic, and molecular data; and (3) Determine the cost-effectiveness of increased respiratory virus
screening and expanded infection control measures to reduce HA-RVI using mathematical models. Completion
of the training and research programs will represent the next step on Dr. Petrie's path toward achieving his
long term goal of establishing an independent research program that uses multidisciplinary laboratory and
analytic methodologies to investigate the transmission of influenza and other respiratory viruses. The expected
research outcomes of the proposed project are, 1) identification of respiratory viruses that, in addition to
influenza, are responsible for the greatest number of HA-RVI and result in the most severe clinical outcomes;
2) development of methodology for improved identification of HA-RVI through integration of clinical,
epidemiologic, and molecular data; and 3) determination of cost-effective diagnostic testing and intervention
implementation strategies for HA-RVI prevention. The proposed research is significant because it is expected
that the outcomes of this work and future studies that build upon it, will lead to reductions in morbidity,
mortality, and healthcare costs associated with HA-RVI. This resear...

## Key facts

- **NIH application ID:** 10083176
- **Project number:** 5K01AI141579-03
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Joshua Glenn Petrie
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $106,212
- **Award type:** 5
- **Project period:** 2019-01-02 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10083176

## Citation

> US National Institutes of Health, RePORTER application 10083176, Hospital-Associated Respiratory Virus Infections: Molecular Epidemiology, Clinical Outcomes, and Cost-Effectiveness of Interventions (5K01AI141579-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10083176. Licensed CC0.

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