# Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1

> **NIH NIH UG3** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2021 · $395,274

## Abstract

PROJECT SUMMARY
While the technological enterprise of magnetic resonance imaging (MRI) generates a host of biomarkers of the
tumor environment, in particular for breast cancer, precious few (and typically only first-order markers) have
been tested beyond single site studies with single workflow processing. To address both the need for advanced
tissue characterization and multi-site translation, we propose a multi-site study of intravoxel incoherent motion
(IVIM) MRI in breast cancer to determine its maximum translational prognostic benefit. The IVIM model, which
includes separate markers of tissue cellularity, vascular volume, and micro-vascular flow, has been successfully
applied in a range of cancers, including breast cancer by the project teams of this proposal. This project will
determine inherent variability of the technique with hardware variation (3 vendors) and software platforms (6
packages), in a 5 site retrospective analysis of clinical breast cancer IVIM data. We will then conduct a
prospective two-site IVIM longitudinal study of patients undergoing neoadjuvant chemotherapy to determine the
best pre- or mid-treatment biomarkers to predict therapeutic response. At each stage, performance will be
evaluated both within each site and in the combined cohort, with the goal of identifying biomarkers that are both
useful and broadly translatable.

## Key facts

- **NIH application ID:** 10084095
- **Project number:** 1UG3CA239861-01A1
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Eric Edward Sigmund
- **Activity code:** UG3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $395,274
- **Award type:** 1
- **Project period:** 2021-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10084095

## Citation

> US National Institutes of Health, RePORTER application 10084095, Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1 (1UG3CA239861-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10084095. Licensed CC0.

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