# Diversity Supplement

> **NIH NIH R01** · RESEARCH TRIANGLE INSTITUTE · 2020 · $141,278

## Abstract

PROJECT SUMMARY/ABSTRACT
 Adolescence and young adulthood are periods of high vulnerability to HIV and unintended pregnancies
for young women in South Africa. Adolescent girls and young women (AGYW) aged 15 to 24 comprise 25%
of new HIV infections in South Africa. Additionally, 18% of AGYW give birth by age 18. HIV risk increases
significantly during pregnancy and postpartum, highlighting the need for efficacious HIV prevention strategies
for this population. The World Health Organization guidelines recommend that women continue using PrEP if
they become pregnant and remain at risk for HIV. However, South Africa has not yet implemented these
recommendations into its national PrEP guidelines. This 2-year diversity supplement seeks to build the
evidence base on PrEP use among pregnant AGYW and aligns with NICHD's Strategic Plan, Setting the
Foundation for Healthy Pregnancies and Lifelong Wellness under the cross-cutting topics of infectious
disease and global health.
 The Specific Aims are:
 Aim 1: Compare pregnancy outcomes (e.g., termination, miscarriage) and birth outcomes (e.g.,
 gestational age, birth weight, birth length, fetal head circumference) between pregnant AGYW
 who uptake PrEP and those who do not.
 Aim 2: Examine the association between pregnancy and PrEP adherence and persistence among
AGYW.
 Aim 3: Use journey mapping to examine and depict pregnant AGYW's experience using PrEP.
 Aim 4: Qualitatively explore provider attitudes and beliefs toward AGYW who are pregnant and use
 PrEP and providers clinical recommendations regarding PrEP use during pregnancy.
 Throughout the supplement period, the proposed candidate will engage in a variety of research and
professional development activities, including participating in didactic trainings, continuing to produce
scholarly research, and applying for additional National Institute of Health (NIH) funding. The activities
comprising this supplement will provide the candidate with opportunities to enhance the necessary skills to
become an independent NIH-funded researcher.
 Preliminary study data will be applied to a future NIH R21 proposal to develop an intervention to improve
PrEP adherence and persistence among pregnant and postpartum AGYW in South Africa.

## Key facts

- **NIH application ID:** 10085105
- **Project number:** 3R01HD094629-04S1
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** Margaret Gichane
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $141,278
- **Award type:** 3
- **Project period:** 2017-09-18 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10085105

## Citation

> US National Institutes of Health, RePORTER application 10085105, Diversity Supplement (3R01HD094629-04S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10085105. Licensed CC0.

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