# Topic 377: Symptom Management and Intervention Roadmaps (STaIRS) (Moonshot)

> **NIH NIH N44** · CAREVIVE SYSTEMS, INC. · 2020 · $1,500,000

## Abstract

Numerous adverse symptoms are under-detected in cancer care resulting1-3 in missed opportunities for
intervention; leading to poor treatment adherence, avoidable hospitalizations, and worse morbidity and
survival. The IOM proposed shaking up the current symptom paradigm from reactive to proactive,
personalized, technology-enabled models of symptom care as a solution to this clinical quality crisis. Such
proactive care models reduce symptom burden, emergency department use, and improve survival. While
commercially-available symptom monitoring and clinical alerting applications proliferate, they lack
personalized, computable algorithms for tailored, evidence-based clinical symptom management. The
Carevive Care Planning System (CPS) is an exception, having commercially deployed symptom monitoring
and assessment tools, clinician-facing content, and computable algorithms for patient self-management of
symptoms since 2014, via a proprietary rules engine. These assets, combined with ONS content and
Carevive’s extensive network of expert advisors and clients, will be leveraged in Phase I into the usercentered
design of computable algorithms for clinician assessment and management of fatigue and
constipation; integrating clinical data to facilitate personalized, evidence-based symptom care superior to
existing reactive and proactive symptom care approaches. Phase I wireframes will be the basis for symptom
expansion, extensive usability and field testing in Phase II, and ultimately efficacy testing and full-scale
commercialization.

## Key facts

- **NIH application ID:** 10085605
- **Project number:** 261201800021C-P00004-9999-1
- **Recipient organization:** CAREVIVE SYSTEMS, INC.
- **Principal Investigator:** Carrie Stricker
- **Activity code:** N44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,500,000
- **Award type:** —
- **Project period:** 2018-09-24 → 2022-01-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10085605

## Citation

> US National Institutes of Health, RePORTER application 10085605, Topic 377: Symptom Management and Intervention Roadmaps (STaIRS) (Moonshot) (261201800021C-P00004-9999-1). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/10085605. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*