# Central Africa International Epidemiologic Database to Evaluate AIDS

> **NIH NIH U01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2020 · $72,342

## Abstract

Program Director/Principal Investigator (Anastos, Kathryn Nash Denis):
Project Summary
Elimination of HIV infection as a cause of human illness and death, and achieving "zero HIV transmission"
have been embraced by the AIDS research and treatment communities as achievable. As HIV care and
treatment programs are implemented throughout Africa, critical advances in research and policy are needed, so
that care and treatment resources can be deployed to optimal benefit: decreasing both new HIV transmissions
and HIV-related morbidity and mortality. Among the most important challenges to maximizing the public
health benefits of HIV care and treatment programs are late diagnosis of HIV-infection, low rates of linkage to
care, and high rates of late ART initiation which in turn are associated with high rates of mortality, more costly
clinical management and continued HIV transmission. In addition there remain unanswered clinical questions
for persons living with HIV (PLWH) even with optimal ART. For PLWH in SubSaharan Africa (SSA), ART
has been highly effective in decreasing HIV-related morbidity (and mortality), but the association of HIV with
metabolic diseases and other conditions of aging (e.g. cancers), and the impact of under- or over-nutrition are
not well defined. Newly funded as CA-IeDEA four years ago, we have built a new Central Africa IeDEA (CA-
IeDEA), and have 1.) Compiled and managed secondary source patient-level data on ~52,000 patients through
both extraction from existing electronic data and new on-the-ground systems for efficient capture of clinical
data in low-resource clinical settings; 2.) Been highly productive scientifically with >20 publications even while
data collection was in development, and 3.) have continued to foster African leadership and build local research
capacity. We propose now to increase the database modestly (to ~80,000 patients) to increase the
representativeness of HIV in the region geographically and in service delivery strategies and success and to
expand our implementation science approaches to optimize short- and long-term HIV care outcomes both in
Central Africa and globally, continue to investigate epidemiologic questions with clinical impact, with a focus
on the comorbidities of aging and women's reproductive health.
OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

## Key facts

- **NIH application ID:** 10086223
- **Project number:** 3U01AI096299-11S1
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Kathryn M. Anastos
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $72,342
- **Award type:** 3
- **Project period:** 2011-07-15 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10086223

## Citation

> US National Institutes of Health, RePORTER application 10086223, Central Africa International Epidemiologic Database to Evaluate AIDS (3U01AI096299-11S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10086223. Licensed CC0.

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