Function of neural activity in developing retina

NIH RePORTER · NIH · R01 · $402,057 · view on reporter.nih.gov ↗

Abstract

The goal of this proposal is to continue studying the development of functional circuits in the retina. Immature retinal neurons spontaneously generate correlated activity in the form of waves of action potentials that sweep across the retinal ganglion cell layer. These retinal waves occur during the developmental period when functional circuits within the retina are emerging and retinal projections to the brain are undergoing a tremendous amount of refinement. Recent discoveries indicate that light penetrating through the closed eyelids may also influence retinal firing patterns during development. In this renewal, we focus on two Aims that explore the impact of early vision on retinal activity and the potential roles it plays in development and early light guided behaviors. In the first Aim, we explore the mechanisms by which spontaneous activity modulates early light responses mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) during the first postnatal week. IpRGCs, which express the photopigment melanopsin, are the first photoreceptors that mature in the retina, and they therefore provide the earliest light-driven signals to the brain. We recently published that blockade of retinal waves increase the number of light responsive cells via an increase in gap junction coupling between ipRGCs and other retinal neurons. Here we explore the mechanisms underlying this activity-dependent modulation of coupling and its function in early light-guided behaviors. In the second Aim, we investigate how retinal waves interact with these emerging visual circuits of the retina during the second postnatal week, just prior to eye-opening. Specifically we will test the novel hypothesis that light stimulation alters the properties of retinal waves and determine whether this light modulation of waves is critical for refinement of retinofugal projections. Experiments are based on state-of-the art technologies that include volumetric two-photon imaging of genetically encoded calcium sensors. This work will address the principles that establish the mechanisms underlying spontaneous activity in developing circuits and the role these principles play in activity- dependent developmental processes. It will also elucidate the principles that govern the normal development of the human nervous system, thus making it possible to understand the origin of neurological birth defects and to devise strategies that enable the nervous system to regenerate functioning neural circuits after injury.

Key facts

NIH application ID
10086481
Project number
5R01EY013528-20
Recipient
UNIVERSITY OF CALIFORNIA BERKELEY
Principal Investigator
Marla Feller
Activity code
R01
Funding institute
NIH
Fiscal year
2021
Award amount
$402,057
Award type
5
Project period
2002-04-01 → 2023-01-31