# CD4_T-cell_Immunity_in_the_Lung

> **NIH NIH R35** · TULANE UNIVERSITY OF LOUISIANA · 2021 · $967,305

## Abstract

Abstract
Pneumonia remains the #1 killer of children in the world and is a leading cause of morbidity and
mortality in children in the US and the #8 cause of mortality in adults. Our laboratory has made
seminal insights in mechanisms underlying host defense against extracelluar pathogens –
particularly in the area of type 17 cytokines –IL-17 and IL-22. We have identified novel
pathways that regulate host immunity against Pneumocystis including CD4+ T-cell intrinsic
IL21R expression and STAT3 activation. We will determine how CD4+ T-cell STAT3 regulates
host resistance and test the specific roles of IL-22, GM-CSF and CD209 isoforms. Furthermore
we will examine the role of IL-22RA2 in regulating the availability of free IL-22 in the lung and
study the contributions of tissue resident memory cells in host defense against bacterial
pneumonia. The research prosed under this R35 will shed new light on pulmonary host
defenses that can be exploited to reduce the global burden of pneumonia mortality and
morbidity.

## Key facts

- **NIH application ID:** 10086497
- **Project number:** 5R35HL139930-04
- **Recipient organization:** TULANE UNIVERSITY OF LOUISIANA
- **Principal Investigator:** JAY K KOLLS
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $967,305
- **Award type:** 5
- **Project period:** 2018-02-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10086497

## Citation

> US National Institutes of Health, RePORTER application 10086497, CD4_T-cell_Immunity_in_the_Lung (5R35HL139930-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10086497. Licensed CC0.

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