# A Longitudinal Study of Endocrine Disruptor Mixtures and Reproductive Aging

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $265,149

## Abstract

Project Summary/Abstract
Exposure to endocrine disrupting chemicals (EDCs) is widespread and these compounds can persist in the
environment and the human body over decades. The population is aging, and women, in particular, can
experience significant morbidity and diminished quality of life with aging. Recent epidemiologic data suggest
that the timing of reproductive aging (the gradual decline in ovarian function with age) and the pattern of
hormonal change during the menopausal transition influence women’s risk of chronic disease and their long-
term health with aging. While numerous studies have examined adverse reproductive health effects and
exposure to EDCs, little is known about how EDCs affect the timing or process of reproductive aging. Further,
most existing epidemiologic studies on this topic have been cross-sectional with studies of age-at-menopause
based on recall, limiting causal inference. In addition, combined exposure to various EDCs and pollutant-
pollutant interactions (mixtures), as well as low-dose and non-monotonic dose-responses have been rarely if at
all addressed. The proposed new epidemiologic study in a multi-ethnic cohort of women seeks to better
understand how EDCs exposure affects the timing and characteristics of reproductive aging. We propose 1) to
assess associations between EDC exposure (polychlorinated biphenyls, chlorinated pesticides, brominated
flame retardants, and perfluorinated compounds) and timing of reproductive aging, including age at
menopause and duration of the menopausal transition; 2) to assess the association between EDC exposure
and hormonal characteristics during the menopausal transition, including levels and patterns of change in
estradiol, follicle stimulating hormone, testosterone, sex-hormone binding globulin, and anti-Müllerian hormone;
and 3) to examine the simultaneous effects of multiple EDCs and their interactions (mixture effects) on these
reproductive aging outcomes using regression methods for high-dimensional covariates (multi-pollutant
approaches). We will also explore effect modification by race/ethnicity and temporal variations in EDCs. We
will capitalize on extensive phenotypic data and biospecimens collected for more than 15 years in an ongoing,
large longitudinal cohort of women, the Study of Women’s Health Across the Nation (n=1,800 with a total of
~14,000 observations). This project addresses strategic priorities of the National Institute of Environmental
Health Sciences, including disease pathogenesis by combined environmental exposures, as well as
environmental health disparities. We will address these issues using innovative analytic approaches likely to
yield new insights on the study of pollution mixtures and human health. The knowledge gained from this
research may guide disease prevention initiatives; enhance women’s health and wellbeing as they age; and
reduce environmental health disparities.

## Key facts

- **NIH application ID:** 10088443
- **Project number:** 5R01ES026964-05
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Sung Kyun Park
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $265,149
- **Award type:** 5
- **Project period:** 2016-08-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10088443

## Citation

> US National Institutes of Health, RePORTER application 10088443, A Longitudinal Study of Endocrine Disruptor Mixtures and Reproductive Aging (5R01ES026964-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10088443. Licensed CC0.

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