# Core B: Glyco-genomics and Bioinformatics

> **NIH NIH P01** · VERSITI BLOOD HEALTH, INC. · 2021 · $272,459

## Abstract

Core B - Project Summary/Abstract
This Program Project will investigate the mechanisms by which glycosylation and glycans may alter the function,
maintenance, differentiation, and overall function of hematopoietic cells. The PPG's approach towards these
questions is to find correlations between the glycosylation state of cells, their proteoglycan repertoire, their
biological responses to injury, and their gene expression programs in model system with altered function of two
key glycosylation enzymes, i.e. ST6Gal1 and β4Gal1T1. The Glycogenomics Core (Core B) will support this
effort by characterizing the gene expression program in various models via sequencing of RNA. The three
Specific Aims of this Core are (Aim 1) to generate and sequence a large number of cDNA libraries derived from
bulk RNA samples isolated from a large pool of cells; (Aim 2) to generate and sequence cDNA libraries from
single cells, and (Aim 3) to conduct the computational processing, initial analysis, and curation of sequencing
data.

## Key facts

- **NIH application ID:** 10088966
- **Project number:** 1P01HL151333-01A1
- **Recipient organization:** VERSITI BLOOD HEALTH, INC.
- **Principal Investigator:** Hartmut Karl-Heinz Weiler
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $272,459
- **Award type:** 1
- **Project period:** 2021-01-01 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10088966

## Citation

> US National Institutes of Health, RePORTER application 10088966, Core B: Glyco-genomics and Bioinformatics (1P01HL151333-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10088966. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*