# Prevention of Vein Graft Failure

> **NIH NIH R01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2021 · $573,747

## Abstract

Project Summary/Abstract
While the “response to injury” associated with pathologic vascular damage has been
described as the initiator of vascular graft failure, there is very little information about the
molecular mediator of this process. We propose that ATP released during surgical
harvest of human saphenous vein activates purinergic receptors (P2X7R) leading to a
cascade of events that promulgate and potentiate the response to injury.
Understanding the role of ATP and P2X7R pathway activation in response to vascular
injury will lead to specific modalities to prevent and treat the injury that occurs during
surgical harvest of HSV. This work will also provide new insights in vascular biology
with potential extensions to other applications such as vascular injury during
angioplasty, transplantation, and trauma.

## Key facts

- **NIH application ID:** 10089464
- **Project number:** 5R01HL070715-17
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Colleen M Brophy
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $573,747
- **Award type:** 5
- **Project period:** 2003-04-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10089464

## Citation

> US National Institutes of Health, RePORTER application 10089464, Prevention of Vein Graft Failure (5R01HL070715-17). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10089464. Licensed CC0.

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