# Leadership Administrative Core

> **NIH NIH U54** · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $147,318

## Abstract

LAC SUMMARY
The scientific mission of this SCORE is to identify stress-immune pathway abnormalities, beginning in fetal
development, that have shared consequences for sex differences in brain circuitry regulating mood and lifelong
recurrent MDD and dysregulation of hormone and immune responses to stress, and autonomic and
neurovascular dysfunction in early midlife. We aim to facilitate transdisciplinary, translational collaboration
among basic and clinical investigators to enhance our understanding of the impact of sex on MDD and central
and peripheral autonomic function and translate this knowledge into sex-selective therapeutics. Further, we
aim to serve as an interdisciplinary resource to train and disseminate findings about sex differences in MDD
and autonomic dysregulation to the scientific and medical communities, policy makers, and the public.
To accomplish our aims in three projects and three cores, we are proposing a series of interdisciplinary and
translational studies from basic and clinical neuroscience and population-level perspectives, integrating
scientists from different disciplines and institutions ranging from the lab bench to the clinical level. In the
Resource Support Core (RSC), we are integrating and introducing novel state-of-the-art technologies, with
some that will cross human and animal work. In the Career Enhancement Core (CEC), educating young
scientists in new approaches and insuring that their future work will translate sex as a biologic variable into
their (and others') thinking in clinical medicine. The Leadership Administrative Core (LAC) is essential in
providing an infrastructure to monitor, integrate, and synergize ongoing activities. The specific aims of the LAC
are to: Coordinate activities of the SCORE; Administer budgets, insuring financial responsibility and
coordination across sites and activities; and Disseminate knowledge through online tools, organizing symposia
and workshops and other avenues to connect the SCORE with the medical community, policy makers, NIH,
and the public.

## Key facts

- **NIH application ID:** 10089490
- **Project number:** 5U54MH118919-02
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** JILL M GOLDSTEIN
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $147,318
- **Award type:** 5
- **Project period:** 2020-02-01 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10089490

## Citation

> US National Institutes of Health, RePORTER application 10089490, Leadership Administrative Core (5U54MH118919-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10089490. Licensed CC0.

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