TR&D 2 SUMMARY The overall performance of the NMR spectrometer impacts every research sample and outcome. Often for complex multidimensional magic-angle spinning solid-state NMR experiments, dozens of experimental parameters require careful adjustment and must be readjusted anytime the environmental conditions drift. Here proposed are approaches to accelerate the setup and configuration of such experiments to maximally leverage the available instrument time, as well as to maintain performance over long periods of signal averaging that can be required for precious research samples that are available only in limited quantity. All aspects of the experimental performance also rely critically on the NMR probe designs, including the radiofrequency electronic circuits and related interfaces to spin the sample, control the temperature and deliver homogeneous pulsed magnetic fields as part of modern multidimensional NMR experiments.