# Cancer Center Support Grant

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $7,827,615

## Abstract

ABSTRACT
Over the past 5 years, the Center sustained its upward trajectory in cancer research excellence and service to
its catchment area, the State of North Carolina. With Dr Sharpless’s appointment to NCI Director, in
consultation with University leadership and the Center’s Scientific Advisors, Dr Earp was re-appointed UNC
Lineberger Comprehensive Cancer Center (LCCC) Director for an additional term. The LCCC continued its
exceptional performance of the past decade with respect to all important metrics including state service. Direct
cost cancer research funding in 2019 increased to $161M of which over $54M comes from NCI; Center
research space under the Director’s authority increased by ~10,000nsf; participation in interventional trials was
over 11,000 accruals for the 5 year period; 36% of the more than 6,000 cancer related publication were
collaborative; construction of a GMP facility was begun and a CAR T program was initiated with multiple INDs
and 8 trials opened; and the Office of Community Outreach Engagement expanded LCCC’s traditional strength
in community-based participatory research and implementation .
The Center’s 324 members span the basic, clinical and population sciences organized into 9 programs with
substantial inter- and intra-programmatic productivity. Faculty additions in the physical and pharmaceutical
sciences created new opportunities in drug discovery, delivery, imaging and early detection. Substantial
investment in faculty, technology and bioinformatics dramatically expanded cancer genetics research including
leadership in the TCGA and expanded use of sequencing in clinical trials. LCCC population scientists initiated
significant new efforts in cancer outcomes with recruitment and infrastructure for analyzing all cancer cases in
our catchment area, as well as new endeavors in cancer communication, health access, survivorship and
molecular epidemiology. Groundbreaking observations in breast cancer minority disparity research emerged
from Center programs. Our basic programs continue to publish high-impact observations that are being
translated into human therapeutics. A trans-Center Global Oncology effort received grants in each of the NCI’s
new competitions. The Center’s continued expansion is driven by remarkable institutional support including
direct support for cancer research from the state legislature. The UNC Lineberger requests continued funding
for: 9 scientific programs; 13 shared resources; Clinical Protocol and Data Management; Protocol Review and
Monitoring System, Developmental Funds, Planning, Leadership and Evaluation and Cancer Research and
Career Enhancement The CCSG budget supports technological and operational expansion for a talented
faculty integrated through cancer center mechanisms towards making advancements in the prevention, early
detection, and treatment of cancer in North Carolina and the nation.

## Key facts

- **NIH application ID:** 10089808
- **Project number:** 2P30CA016086-45
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** H. Shelton Earp
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $7,827,615
- **Award type:** 2
- **Project period:** 1997-06-01 → 2025-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10089808

## Citation

> US National Institutes of Health, RePORTER application 10089808, Cancer Center Support Grant (2P30CA016086-45). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10089808. Licensed CC0.

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