# Shared Resource 01: Biomedical Informatics (BISR)

> **NIH NIH P30** · OHIO STATE UNIVERSITY · 2021 · $151,921

## Abstract

PROJECT SUMMARY – BIOINFORMATICS SHARED RESOURCE (BISR)
The BISR is an essential shared resource that supports a wide range of studies with bioinformatics and
computational biology needs, ranging from next generation sequencing (NGS) to data management in population
science studies. Housed within the Department of BMI, the BISR's goal is to leverage a variety of informatics
services, ranging from analysis of omics datasets to patient/participant-centered data instrumentation, access,
and management tools and processes. The Specific Aims of the BSR are to: 1) Provide state of the art
bioinformatics and computational biology services; and 2) Provide OSUCCC investigators with services,
expertise and access to technology platforms in support of heterogeneous and multi-dimensional biomedical
data management requirements. Over the current grant cycle, Drs. Kevin Coombes (TT) and Lang Li (CB)
assumed leadership of BISR, replacing Drs. Philip Payne and Jeffrey Parvin. During the current funding cycle, a
Memorandum of Understanding (MOU) was established for the Department of Biomedical Informatics (BMI) and
the OSUCCC to support 5 faculty at 10% per year for 3 years within BISR as they transition to grant funding, on
a rolling basis, to provide non-chargeable, cancer focused bioinformatics work for OSUCCC membership and/or
cancer focused researchers. Additional major changes for BISR include supporting the enhancement of the
Genomics Shared Resource (GSR) to incorporate newly developed shared services with Nationwide Children's
Hospital (NCH); and added capabilities to support studies involving data from single-cell sequencing, long-read
(third generation) sequencing, metabolomics, and metagenomics. BISR has added five new faculty to support
the areas of (1) computational optimization for drug sensitivity prediction (Cheng), (2) proteomics, and functional
annotation of DNA non-coding regions (Zhang), (3) metabolomics and metagenomics (Mathe), (4) single-cell
sequencing (Ma), and (5) long-read sequencing (Au). BISR supported Biospecimen Services Shared Resource
(BSSR) projects (Total Cancer Care [TCC] and the Oncology Research Information Exchange Network [ORIEN])
by establishing a data warehouse of patient records with de-identified data. During the current funding cycle, the
BISR supported 115 publications (25 > 10 impact factor), 134 users, and 32 NCI grants including 5 P01s, 2 P50s,
13 R01s, 3 R21s, 1 R50, 2 U01s, 1 U10, 1 UG1, involving members from all five programs. Over the next grant
cycle, BISR will enhance services for “integromics”, e.g., the integration of disparate source of both omics and
clinical data. BISR will be a critical part of the Immune Monitoring and Discovery Platform (IMDP), an overarching
approach for fostering interactions among shared resources for complex immuno-oncology projects. The annual
budget of the BISR is $1,122,279, yet the CCSG request is $106,905. As such, the BISR leverages extensive
institutional support and seek...

## Key facts

- **NIH application ID:** 10090004
- **Project number:** 2P30CA016058-45
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** Kevin Robert Coombes
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $151,921
- **Award type:** 2
- **Project period:** 1997-09-12 → 2025-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10090004

## Citation

> US National Institutes of Health, RePORTER application 10090004, Shared Resource 01: Biomedical Informatics (BISR) (2P30CA016058-45). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10090004. Licensed CC0.

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