# COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health

> **NIH NIH P20** · EMMA PENDLETON BRADLEY HOSPITAL · 2021 · $2,031,442

## Abstract

PROJECT SUMMARY ABSTRACT
 This COBRE will establish a Center on Sleep and Circadian Rhythms in Child and Adolescent Mental
Health at the EP Bradley Hospital in Rhode Island. Bradley Hospital is unique in the US as a psychiatric
institution exclusively focused on children and a national resource for research in child and adolescent
psychiatry. Links between mental illness and sleep are indisputable; probing and identifying the links from
sleep and circadian rhythms to pediatric mental illness and mental health can identify important pathways to
prevention and early intervention, not the least because these factors are amenable to behavioral change and
to defined therapeutic targeting. This COBRE aims to build a bridge from the sleep and circadian knowledge
base and relevant research methods to the outstanding mental health research and clinical care that
characterize Bradley Hospital. The proposed COBRE Center would be the first and only NIH-funded research
center to have an explicit focus on sleep, circadian rhythms, and pediatric mental health. The Center will train,
mentor, and support junior investigators toward independent research careers. The Center’s research Cores
will host training in the assessment of pediatric mental health and in sleep and circadian theory, science, and
methods. The objective of this COBRE Center is to establish and build a comprehensive and sustainable
resource to support the growth of research in pediatric sleep, circadian rhythms, and mental health while
providing mentorship of junior Project Leaders for research and for transitioning to independent scientific
careers with external funding. The Center is committed to diversity in faculty, mentors, investigators, research
approaches and methods, and research participants. Four promising young investigators have each proposed
a project that highlights the diverse and complex nature of this endeavor. Project 1 will measure sleep,
circadian timing, and fMRI to assess Self Critical Rumination and Self Reassurance in adolescents at risk for
suicidal thoughts and actions. Project 2 evaluates sleep patterns and circadian timing in youth who have a
rare DNA copy number variant associated with autism and schizophrenia and includes a circadian clock gene.
Project 3 assess in school children (grades 1-3) how green space use impacts sleep and mental health.
Project 4 uses an intensive sleep and chronobiology in-lab approach to determine how sleepiness and memory
in early adolescents with attention deficit hyperactivity disorder (ADHD) are affected by sleep bioregulatory
factors. The ultimate goal of this COBRE is to ease the burden of these issues for children, adolescents, and
their families through enhancing the research workforce and capabilities. The promise of this COBRE to fulfill
its place as a true center of biomedical research excellence is strong, and the most important, special, and
notable aspect of this proposed center is the vulnerable population that forms the he...

## Key facts

- **NIH application ID:** 10090146
- **Project number:** 1P20GM139743-01
- **Recipient organization:** EMMA PENDLETON BRADLEY HOSPITAL
- **Principal Investigator:** Mary A Carskadon
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,031,442
- **Award type:** 1
- **Project period:** 2021-04-06 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10090146

## Citation

> US National Institutes of Health, RePORTER application 10090146, COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health (1P20GM139743-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10090146. Licensed CC0.

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