# Vitreoretinal Surgery via Robotic Microsurgical System with Image Guidance, Force Feedback, Virtual Fixture, and Augmented Reality > **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $407,448 ## Abstract PROJECT SUMMARY/ABSTRACT The aims of the present proposal are to extend our work with the Intraocular Robotic Interventional and Surgical System (IRISS) and augment it for teleoperated vitreoretinal surgery. Although novel technologies such as intraoperative optical coherence tomography (i-OCT) have been developed, vitreoretinal surgeons still lack critical information during surgery (e.g., the distance between pre-retinal membrane and retina) due to inadequate display and feedback. In addition, physiological capabilities are a limiting factor because the retina is one of the smallest and most delicate tissues of the human body. The rate of surgical failure in complex retinal cases remains high (10–15%) due to the limits of current surgical capabilities, thereby condemning these patients to blindness [1-3]. Our group has developed the IRISS [4-10] through a combination of internal funding and a recent R21 grant (NIH/R21EY024065). This support enabled our group to develop the IRISS platform to perform fully automated cataract surgery on ex-vivo pig eyes. We have also demonstrated the ability of the IRISS to perform safe- motion guidance for lens removal based on per-operative, real-time anatomical detection, and teleoperated capabilities for vitreoretinal maneuvers, including retinal vein cannulation and core vitrectomy [4]. Furthermore, Raven II, an open-source surgical robotics system [11-22], was co-developed by Rosen over the past 16 years for general minimally invasive surgery. In the present study, the surgical cockpit of the Raven II system will serve as the foundation of the user interface for the improved robotic surgical system. The accumulated experience of our group through this previous work will guide the proposed research effort from the stringent clinical requirements to the design, development, and evaluation of the proposed system. The present study is composed of three independent, parallel tracks. First, the mechanical design and assembly of the robotic surgical system will be improved to achieve tool-tip positional precision of 5 µm, approximately ten times more precise than a human surgeon [23]. Second, we will enhance the surgeon's abilities in sensing and interpreting anatomical details during retinal manipulation by applying high-resolution (10 µm), real-time intraoperative i-OCT scans to detect anatomical features critical to specific vitreoretinal procedures. Third, surgical features of interest will be presented to the surgeon via a human–robot surgical cockpit that provides innovative 3D, augmented-reality visualization and auditory and haptic feedback. Each aim will be assessed by a series of evaluation protocols to ensure their success. The safety and efficacy of the system will also be compared with and without the proposed improvements (robotic control, enhanced sensing, and augmented feedback) on a virtual reality simulator in addition to phantom and biological eye models chosen to best assess surgical outcome. ... ## Key facts - **NIH application ID:** 10090474 - **Project number:** 5R01EY029689-03 - **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES - **Principal Investigator:** Jean-Pierre Hubschman - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2021 - **Award amount:** $407,448 - **Award type:** 5 - **Project period:** 2019-02-01 → 2024-01-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10090474 ## Citation > US National Institutes of Health, RePORTER application 10090474, Vitreoretinal Surgery via Robotic Microsurgical System with Image Guidance, Force Feedback, Virtual Fixture, and Augmented Reality (5R01EY029689-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10090474. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*